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   Table of Contents      
LETTER TO THE EDITOR
Year : 2017  |  Volume : 65  |  Issue : 11  |  Page : 1266

Reply to Conjunctival leiomyosarcoma: A case report and review of literature


Ophthalmology Service, University Hospital of Vigo, Vigo, Spain

Date of Web Publication13-Nov-2017

Correspondence Address:
Tania López Montes
Ophthalmology Service, Hospital do Meixoeiro, Vigo 36200
Spain
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijo.IJO_759_17

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How to cite this article:
Montes TL. Reply to Conjunctival leiomyosarcoma: A case report and review of literature. Indian J Ophthalmol 2017;65:1266

How to cite this URL:
Montes TL. Reply to Conjunctival leiomyosarcoma: A case report and review of literature. Indian J Ophthalmol [serial online] 2017 [cited 2019 Oct 22];65:1266. Available from: http://www.ijo.in/text.asp?2017/65/11/1266/218082

Sir,

I thank the author for the interest shown in our published article and appreciate the new information reported.[1]

In fact, the number of reported cases of smooth muscle tumor (SMT) arising in the setting of human immunodeficiency virus (HIV) infection has been increasing for the last three decades. Coinfection with Epstein-Barr virus (EBV) appears to be a necessary cofactor for the development of these tumors.[2],[3] These EBV-related SMT also were reported in posttransplant immunosuppressed patients and individuals with autoimmune disease or iatrogenic immunosuppression.[4] None of these conditions, including HIV infection, was present in the patient of our case report. Detection of EBV was performed in the tumor tissue with negative results.

Although EBV-SMT affects especially patients who are young, severely immunosuppressed and have multifocal tumors, it is true that EBV-SMT should be included in the differential diagnosis of any SMT occurring in uncommon sites (e.g., conjunctiva).[2] These tumors appear to have a more favorable prognosis than conventional leiomyosarcoma.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
  References Top

1.
Montes TL, Agra MV, Alonso MS, Lorenzo AO. Conjunctival leiomyosarcoma: A case report and review of literature. Indian J Ophthalmol 2017;65:406-8.  Back to cited text no. 1
[PUBMED]  [Full text]  
2.
Moore Dalal K, Antonescu CR, Dematteo RP, Maki RG. EBV-associated smooth muscle neoplasms: Solid tumors arising in the presence of immunosuppression and autoimmune diseases. Sarcoma 2008;2008:859407.  Back to cited text no. 2
[PUBMED]    
3.
Issarachaikul R, Shuangshoti S, Suankratay C. Epstein-Barr virus-associated smooth muscle tumors in AIDS patients: A largest case (series). Intern Med 2014;53:2391-6.  Back to cited text no. 3
[PUBMED]    
4.
Purgina B, Rao UN, Miettinen M, Pantanowitz L. AIDS-related EBV-associated smooth muscle tumors: A Review of 64 published cases. Patholog Res Int 2011;2011:561548.  Back to cited text no. 4
[PUBMED]    




 

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