Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 172
  • Home
  • Print this page
  • Email this page

   Table of Contents      
Year : 2018  |  Volume : 66  |  Issue : 11  |  Page : 1531

Unilateral macular drusen in a young female

1 The Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Philadelphia, Pennsylvania, PA, USA; Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA
2 The Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Philadelphia, Pennsylvania, PA, USA

Date of Web Publication25-Oct-2018

Correspondence Address:
Dr. Kareem Sioufi
Retina Service, Wills Eye Hospital, Thomas Jefferson University, 840 Walnut Street, Philadelphia, 19107-5109 PA
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijo.IJO_1349_18

Rights and Permissions

How to cite this article:
Sioufi K, Talcott KE, Spirn MJ. Unilateral macular drusen in a young female. Indian J Ophthalmol 2018;66:1531

How to cite this URL:
Sioufi K, Talcott KE, Spirn MJ. Unilateral macular drusen in a young female. Indian J Ophthalmol [serial online] 2018 [cited 2018 Nov 17];66:1531. Available from:

  Case Top

A 27-year-old female with a history of systemic lupus erythematosus (SLE) was referred for evaluation of unilateral macular drusen. Family history of familial drusen was negative. On examination, visual acuity was 20/25 in the right eye (OD) and 20/20 in the left eye (OS). Funduscopy OD revealed numerous (>80) yellowish temporal perifoveal lesions (A). Funduscopy OS was normal (B).

  What is Your Next Step? Top

  1. Start the Age-Related Eye Disease Study (AREDS) vitamins
  2. Enhanced depth imaging optical coherence tomography (EDI OCT)
  3. Fluorescein angiography
  4. Bevacizumab intravitreal injection.

Illustration – [Figure 1].

  Findings Top

EDI OCT OD showed drusen-like deposits (DLDs) located between the retinal pigment epithelium and Bruch membrane, with the largest DLD measuring 232 μm in base and 89 μm in elevation (C). Macula OS was intact by EDI OCT (D). Further systemic work-up revealed no evidence of glomerulonephritis.

  Diagnosis: drusen Like Deposits in SLE. Top

  Correct Answer: B. Top

  Discussion Top

Ocular involvement in SLE can occur in up to 30% of patients.[1] Asymptomatic choroidal alteration and DLDs in patients with SLE glomerulonephritis were first described in 2011 by Baglio et al. using indocyanine green angiography.[2] Later in 2017, Invernizzi et al. documented presence of DLDs, with or without glomerulonephritis, however, they found that patients with glomerulonephritis demonstrated more DLDs per eye, larger DLDs, and DLDs involvement of >3 quadrants (all P < 0.03).[3] We advise patients with SLE to have a thorough dilated funduscopic examination. A screening EDI OCT should be considered in patients with SLE.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

  References Top

Palejwala NV, Walia HS, Yeh S. Ocular manifestations of systemic lupus erythematosus: A review of the literature. Autoimmune Dis 2012;2012:290898.  Back to cited text no. 1
Baglio V, Gharbiya M, Balacco-Gabrieli C, Mascaro T, Gangemi C, Di Franco M, et al. Choroidopathy in patients with systemic lupus erythematosus with or without nephropathy. J Nephrol 2011;24:522-9.  Back to cited text no. 2
Invernizzi A, dell'Arti L, Leone G, Galimberti D, Garoli E, Moroni G, et al. Drusen-like deposits in young adults diagnosed with systemic lupus erythematosus. Am J Ophthalmol 2017;175:68-76.  Back to cited text no. 3


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
What is Your Nex...
Diagnosis: druse...
Correct Answer: B.

 Article Access Statistics
    PDF Downloaded292    
    Comments [Add]    

Recommend this journal