Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 1415
  • Home
  • Print this page
  • Email this page

   Table of Contents      
Year : 2018  |  Volume : 66  |  Issue : 11  |  Page : 1623

Differential corneal involvement in xeroderma pigmentosum

Cornea and Anterior Segment Services, Tej Kohli Cornea Institute, L. V. Prasad Eye Institute, Hyderabad, Telangana, India

Date of Web Publication25-Oct-2018

Correspondence Address:
Dr. Sunita Chaurasia
Tej Kohli Cornea Institute, L. V. Prasad Eye Institute, L. V. Prasad Marg, Banjara Hills, Hyderabad - 500 034, Telangana
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijo.IJO_667_18

Rights and Permissions

How to cite this article:
Chaurasia S. Differential corneal involvement in xeroderma pigmentosum. Indian J Ophthalmol 2018;66:1623

How to cite this URL:
Chaurasia S. Differential corneal involvement in xeroderma pigmentosum. Indian J Ophthalmol [serial online] 2018 [cited 2019 Oct 20];66:1623. Available from:

A 7-year-old girl was brought with an inability to open the eyes in bright light for the past several years. Examination revealed multiple hyperpigmented skin nevi involving the face, neck, arms, and feet suggestive of clinical diagnosis of xeroderma pigmentosum. The child was extremely photophobic. Lid margin was irregular with severe loss of lashes in the lower eyelid of both eyes. Conjunctiva was dry, atrophic, and pigmented. Cornea showed haze, edema, and vascularization. The left eye showed an area of corneal melt and perforation. As seen in both eyes, the upper one-third of the peripheral cornea was relatively unaffected corresponding to the area that is covered by eyelids [Figure 1]. The selective sparing of the superior part of the cornea is explained by the protective effect of the upper eyelid. This clinical observation emphasizes the fact that the corneal changes in xeroderma are secondary to the cumulative effect of exposure of ultraviolet radiation on the affected area. The disabling corneal changes can be prevented if adequate solar protection is emphasized at an early stage of life.
Figure 1: Digital photograph showing corneal haze and edema in both eyes. The left eye shows a perforation. The sun-exposed areas of the corneas (inferior) show a more severe involvement compared with the area protected by the upper eyelids

Click here to view

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.


  [Figure 1]


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
Article Figures

 Article Access Statistics
    PDF Downloaded85    
    Comments [Add]    

Recommend this journal