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ORIGINAL ARTICLE
Year : 2018  |  Volume : 66  |  Issue : 8  |  Page : 1080-1083

The protective effect of simvastatin against ultraviolet B-induced corneal endothelial cell death


1 Department of Medical Research and Development, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan
2 Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan
3 Department of Biomedical Sciences and Engineering, Graduate Institute of Systems Biology and Bioinformatics, National Central University, Chungli; Department of Ophthalmology, Hsin Sheng Junior College of Medical Care and Management, Longtan, Taiwan

Correspondence Address:
Dr. Chan-Yen Kuo
Department of Biomedical Sciences and Engineering, Graduate Institute of Systems Biology and Bioinformatics, National Central University, Chung-li
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijo.IJO_93_18

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Purpose: Excessive ultraviolet B (UVB) exposure causing corneal endothelium injury, including apoptosis, is a serious condition. Therefore, drugs that can inhibit apoptosis in corneal endothelial cells represent an effective strategy. Simvastatin is widely used as a specific inhibitor of 3-hydroxy-3-methyl-glutaryl-CoA reductase, can reduce levels of low density lipoprotein (LDL) cholesterol, and exerts anti-inflammatory effects. However, the protective effect of simvastatin on corneal endothelial cells remains unclear. Therefore, the aim of this study was to elucidate whether UVB promotes the initiation of apoptosis in corneal endothelial cells and injury reversible by simvastatin treatment. Methods: We detected the cell viability, subG1 population, and caspase-3 activity. Results: Results showed that simvastatin alleviates UVB-induced cell death, cell apoptosis, and caspase-3 activity. Conclusion: Our findings indicated that simvastatin alleviated UVB-induced corneal endothelial cell apoptosis via caspase-3 activity.


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