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LETTERS TO THE EDITOR
Year : 2018  |  Volume : 66  |  Issue : 9  |  Page : 1380

Response to: Transzonular drug delivery during cataract surgery: Is dropless cataract surgery really beneficial?


1 Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
2 Srimati Kanuri Santhamma Centre for Vitreoretinal Disease, L V Prasad Eye Institute, Hyderabad, Telangana, India

Date of Web Publication20-Aug-2018

Correspondence Address:
Prof. Namrata Sharma
Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Room- 482, 4th Floor, New Delhi - 110 029
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijo.IJO_1040_18

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How to cite this article:
Maharana PK, Chhablani JK, Das T, Kumar A, Sharma N. Response to: Transzonular drug delivery during cataract surgery: Is dropless cataract surgery really beneficial?. Indian J Ophthalmol 2018;66:1380

How to cite this URL:
Maharana PK, Chhablani JK, Das T, Kumar A, Sharma N. Response to: Transzonular drug delivery during cataract surgery: Is dropless cataract surgery really beneficial?. Indian J Ophthalmol [serial online] 2018 [cited 2024 Mar 28];66:1380. Available from: https://journals.lww.com/ijo/pages/default.aspx/text.asp?2018/66/9/1380/239324



Sir,

We thank the authors for their keen interest in our article.[1] The authors have provided a concise update on the pros and cons of “Transzonular injection of antibiotics and steroids (dropless cataract surgery) technique”.[2] At first look, the technique appears potentially useful especially in the setting of large-volume surgeries and poor understanding of the patient about the treatment regimen, which is quite common in India. Several early reports have proven its efficacy too.[3],[4] However, it is not fair to make any conclusive statement regarding this unique method of drug delivery as clinical trials are still going on.

There are several issues that need to be addressed especially in relevance to Indian setup. First, the drug is still not available in India. Second, it is not possible to say it will be cost-effective compared with the topical drugs as it is still not launched in India. Moreover, with the recommendation of use of generic medications by the state, the cost of topical drugs has come down significantly. Third, injection of triamcinolone acetonide can lead to persistent vitreous haze. This may mask an early sign of endophthalmitis and this aspect needs to be studied in future trials. Inserting the cannula through the zonules and injecting the drug may not be that easy for general practitioners in developing countries like India. Inadvertent zonular damage is definitely a potential complication. Finally, in cases of steroid responders, topical drugs are definitely better as steroids can be withdrawn which is simply not possible with transzonular injection.

To conclude, the technique of “Transzonular injection of antibiotics and steroids (dropless cataract surgery)” appears to be a safe and effective technique. It may be extremely useful in Indian setup. Although the initial results are quite encouraging, the results of ongoing trial may further bring more clarity.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Maharana PK, Chhablani JK, Das TP, Kumar A, Sharma N. All India ophthalmological society members survey results: Cataract surgery antibiotic prophylaxis current practice pattern 2017. Indian J Ophthalmol 2018;66:820-4.  Back to cited text no. 1
[PUBMED]  [Full text]  
2.
Pandey SK, Sharma V. Transzonular drug delivery during cataract surgery: Is dropless cataract surgery really beneficial?. Indian J Ophthalmol 2018;66:1377-9.  Back to cited text no. 2
  [Full text]  
3.
Lindstrom RL, Galloway MS, Grzybowski A, Liegner JT. Dropless cataract surgery: An overview. Curr Pharm Des 2017;23:558-64.  Back to cited text no. 3
    
4.
Fisher BL, Potvin R. Transzonular vitreous injection vs. a single drop compounded topical pharmaceutical regimen after cataract surgery. Clin Ophthalmol 2016;10:1297-303.  Back to cited text no. 4
    




 

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