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CASE REPORT
Year : 2019  |  Volume : 67  |  Issue : 10  |  Page : 1762-1765

Case report on two diabetic donor eyes with no retinopathy: Clinicopathological and molecular studies


1 RS Mehta Jain Department of Biochemistry and Cell Biology, Vision Research Foundation, Chennai, India
2 Department of Uveitis, Medical Research Foundation, Chennai, India
3 Shri Bhagwan Mahavir Vitreoretinal Services, Medical Research Foundation, Chennai, India
4 Aditya Jyot Eye Hospital, Mumbai, India

Correspondence Address:
Dr. Narayanasamy Angayarkanni
RS Mehta Jain Department of Biochemistry and Cell Biology, KBIRVO, Vision Research Foundation, Sankara Nethralaya, 41, College Road, Chennai - 600 006, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijo.IJO_400_19

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We were intrigued to analyze donor eyes of two individuals without retinopathy even after 40 years of type 2 diabetes mellitus. Targeted molecular factors associated with angiogenesis and the key antioxidant enzymes in retinal tissue were analyzed. Accordingly PEDF, Adiponectin and Paraoxonase 2 showed augmented mRNA expression in both the retina with no significant change in VEGF expression. Vitreous showed increased PEDF protein in donor 1 and Adiponectin in donor 2 with no change in VEGF protein. This study highlights the profile of specific molecular factors that contribute to the non-development of diabetic retinopathy changes in these individuals.


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