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   Table of Contents      
COMMENTARY
Year : 2019  |  Volume : 67  |  Issue : 11  |  Page : 1828-1829

Commentary: Targeting herpetic keratitis by immunomodulation of IL-27 signaling


Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad, Telangana, India

Date of Web Publication22-Oct-2019

Correspondence Address:
Dr. Joveeta Joseph
Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad - 500 034, Telangana
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijo.IJO_1364_19

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How to cite this article:
Joseph J. Commentary: Targeting herpetic keratitis by immunomodulation of IL-27 signaling. Indian J Ophthalmol 2019;67:1828-9

How to cite this URL:
Joseph J. Commentary: Targeting herpetic keratitis by immunomodulation of IL-27 signaling. Indian J Ophthalmol [serial online] 2019 [cited 2019 Nov 18];67:1828-9. Available from: http://www.ijo.in/text.asp?2019/67/11/1828/269610



Herpetic stromal keratitis (HSK) is a chronic inflammatory disease triggered by infection of the cornea with HSV-1.[1] Evidence from mouse models of HSK suggest that the inflammation is mediated preferentially by CD4+ T cells in part through the production of Th1 cytokines (IFN-γ and IL-2).[2] A prominent component of counter-inflammation is the activity of regulatory T cells (Treg), especially those that can be identified because they express the Foxp3 transcription factor, which controls their regulatory activity. When the Treg response is absent or impaired, stromal keratitis lesions are more prolonged and consequential. Unfortunately, the function of Treg can be unstable in an inflammatory environment, with the cells themselves losing their regulatory function and even taking on a pro-inflammatory role and then contributing to tissue damage.[3] Because HSK is an immunopathological process, knowledge of the underlying immunological mechanisms is a prerequisite for the design of immunology-based therapeutic intervention.

In this issue of the Indian Journal of Ophthalmology, Xia et al. investigate the role of IL-27 signaling in HSV-1 infection using a mouse model of HSK.[4] IL-27 is a heterodimeric cytokine composed of the subunits p28 and EBI3, which bind to the heterodimeric IL-27Rα/gp130 receptor.[4] Although it was initially linked with the development of Th1 responses, it is now recognized as a potent antagonist of different classes of inflammation through its ability to directly modify CD4+ and CD8+ T cell effector functions, to induce IL-10, and to promote specialized T regulatory cell responses. Xia et al. provide evidence that IL-27 acts as a pathogenic pro-inflammatory cytokine and upregulate CD4+ Foxp3+ Tregs production during the CD4+ T-cell mediated immunity against HSV-1, which ultimately resulted in promoting the progression of HSK and poor prognosis. The data also suggested that administration of anti-IL-27 antibody decreases the severity of HSK and inhibits CD4+ T Cells infiltration in infected corneas but did not affect the expression of IL-17, IFN-γ, and IL-10 in the cervical DLNs of HSK mice which confirmed that the amelioration in inflammatory response observed in anti-IL-27-treated mice was not associated with the altered Th1, Th2, Th17 responses. Additionally, anti-IL-27 treatment did not alter the viral burden in the cornea as well which proved that the corneal pathological lesions in HSK mice are not the direct aftermath of viral replication in the cornea.

Maertzdorf et al. have previously also reported that Th17 cells also infiltrate to the HSV-infected cornea and possibly are involved in HSK pathogenesis.[5]

These data provide important guidance to therapeutic approaches in the HSV-1 cure agenda. Currently, the acute and epithelial forms of SK are usually controlled using anti-viral drugs. However, chronic forms of stromal keraritis, which are inflammatory in nature, require the addition of a topical corticosteroid to the anti-viral treatment regimen. The present results indicate that the ocular surface provides a readily accessible site for DNA immunization and is suitable for both immune induction and modulation of the nature of the immune response that is induced. The maturation of this literature should be accompanied by attempts to translate these findings from experimental models into human diseases and by efforts to define where IL-27 might represent a viable therapeutic target.

Acknowledgements

Hyderabad Eye Research Foundation.



 
  References Top

1.
Hendricks RL. Immunopathogenesis of viral ocular infections. Chem Immunol 1999;73:120-36.  Back to cited text no. 1
    
2.
Abramson O, Qiu S, Erle DJ. Preferential production of interferon- gamma by CD4+ T cells expressing the homing receptor integrin alpha4/beta7. Immunology 2001;103:155-63.  Back to cited text no. 2
    
3.
Suvas S, Azkur AK, Kim BS, Kumaraguru U, Rouse BT. CD4+CD25+ regulatory T cells control the severity of viral immunoinflammatory lesions. J Immunol 2004;172:4123-32.  Back to cited text no. 3
    
4.
Xia L, Tan T, Li Y, Zhong Q, Shi M. Blockade of IL?27 signaling ameliorates herpes stromal keratitis with upregulated CD4+ Foxp3+ regulatory T cells influx in mice. Indian J Ophthalmol 2019;67:1821-8.  Back to cited text no. 4
  [Full text]  
5.
Maertzdorf J, Osterhaus AD, Verjans GM. IL-17 expression in human herpetic stromal keratitis: Modulatory effects on chemokine production by corneal fibroblasts. J Immunol 2002;169:5897-903.  Back to cited text no. 5
    




 

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