Glyxambi
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 286
  • Home
  • Print this page
  • Email this page


 
   Table of Contents      
ONE MINUTE OPHTHALMOLOGY
Year : 2019  |  Volume : 67  |  Issue : 4  |  Page : 449

Papilledema or pseudopapilledema?


Oncology Service, Wills Eye Hospital, Thomas Jefferson University, 840 Walnut Street, 14th Floor, Philadelphia, PA 19107, USA

Date of Web Publication22-Mar-2019

Correspondence Address:
Dr. Carol L Shields
Ocular Oncology Service, 840 Walnut Street, Suite 1440, Philadelphia, PA 19107
USA
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijo.IJO_2013_18

Rights and Permissions

How to cite this article:
Liu L, Yu MD, Shields CL. Papilledema or pseudopapilledema?. Indian J Ophthalmol 2019;67:449

How to cite this URL:
Liu L, Yu MD, Shields CL. Papilledema or pseudopapilledema?. Indian J Ophthalmol [serial online] 2019 [cited 2019 Jun 18];67:449. Available from: http://www.ijo.in/text.asp?2019/67/4/449/254721




  Case Top


A 6-year-old systemically healthy Caucasian boy presented with decreased vision in the left eye (OS) for 10 months. Visual acuity was 20/30 in the right eye (OD) and 20/400 OS with relative afferent pupillary defect OS. Intraocular pressures were normal in both eyes (OU). Funduscopy revealed swollen, elevated optic disc OU, with indistinct disc margin and cup/disc ratio of 0 [Figure 1]a. Superotemporal to the disc in OS, there was subretinal hemorrhage with central subretinal fibrosis. Blood pressure and body temperature were normal.
Figure 1: (a) Fundus photograph demonstrating subretinal hemorrhage with subretinal fibrosis superotemporal to the disc OS. The lesion is further visualized using (b) B-scan ultrasonography, (c) FA, and (d and e) OCT (horizontal orientation)

Click here to view



  What is Your Next Step? Top


  1. Consult pediatric neurosurgery for assessment
  2. Perform lumbar puncture with opening pressure
  3. Order toxoplasma and toxocara serology
  4. Perform additional ocular diagnostic imaging with B-scan ultrasonography, optical coherence tomography (OCT), and fluorescein angiography (FA).



  Findings Top


B-scan ultrasonography showed a small scleral canal and optic disc hyperreflectivity, suggestive of calcified optic disc drusen (ODD) OU [Figure 1]b. FA showed early hyperfluorescence with late staining at the site of blood, suggestive of choroidal neovascular membrane (CNVM) [Figure 1]c. OCT over the hemorrhage [Figure 1]d revealed subretinal hyperreflective CNVM with buried drusen at the optic disc [Figure 1]e. Brain and orbit magnetic resonance imaging (MRI) showed no mass. These findings were consistent with CNVM arising from ODD. Intravitreal bevacizumab resulted in CNVM regression after 1 month.


  Diagnosis Top


ODD with CNVM.


  Correct Answer: D. Top



  Discussion Top


Bilateral optic disc swelling can result from papilledema or pseudopapilledema. The latter is a group of optic disc abnormalities including hypoplastic, dysplastic, or tilted optic disc, persistent hyaloid remnants, ODD, and others.[1] True disc swelling warrants immediate MRI evaluation for intracranial mass or venous sinus thrombosis. ODD are acellular deposits believed to result from a tight scleral canal that leads to axoplasmic stasis.[2] ODD are present in 0.4%–2.4% of eyes on autopsy and 14.6% by OCT.[1] ODD are bilateral in 75%, increase in size and calcification with age, and can cause visual field defects.[2] CNVM is a fairly common complication, found on OCT in 24 of 98 pediatric eyes (24.5%) with ODD. The CNVM typically responds to intravitreal anti- vascular endothelial growth factor medication.[3]

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Gema R, Aki K, Victoria de J, Noelia O, Francisco Jose MN. Optical coherence tomography to differentiate papilledema from pseudopapilledema. Curr Neurol Neurosci Rep2017;17:74-87.  Back to cited text no. 1
    
2.
Claudia AH, Flemming S, Heinrich W. Optic disk drusen. Surv Ophthalmol 2002;47:515-32.  Back to cited text no. 2
    
3.
Jared ED, Sharon FF, Mays A El-D. The incidence of neovascular membranes and visual field defects from optic nerve head drusen in children. J AAPOS2016;20:44-8.  Back to cited text no. 3
    


    Figures

  [Figure 1]



 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
Case
What is Your Nex...
Findings
Diagnosis
Correct Answer: ...
Discussion
References
Article Figures

 Article Access Statistics
    Viewed1096    
    Printed7    
    Emailed0    
    PDF Downloaded491    
    Comments [Add]    

Recommend this journal