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ORIGINAL ARTICLE
Year : 2019  |  Volume : 67  |  Issue : 5  |  Page : 648-653

Macular ganglion cell complex parameters by optical coherence tomography in cases of multiple sclerosis without optic neuritis compared to healthy eyes


1 Department of Ophthalmology, Faculty of Medicine, Cairo University, Cairo, Egypt; Department of Ophthalmology, Specialised Medical Hospital, Riyadh, Saudi Arabia
2 Imam Mohammed bin Saud Islamic University College of Medicine; Department of Ophthalmology, Specialised Medical Hospital, Riyadh, Saudi Arabia
3 Department of Research, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia

Correspondence Address:
Dr. Nancy M Lotfy
Department of Ophthalmology, Faculty of Medicine, Cairo University. Al-Saray Street, El Manial, Postal Code: 11956, Cairo

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijo.IJO_1378_18

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Purpose: To compare different macular thickness parameters and peripapillary retinal nerve fiber layer (RNFL) thickness between recently diagnosed cases of multiple sclerosis (MS) without optic neuropathy (ON) and healthy individuals. Methods: This cross-sectional study was performed between June 2014 and June 2015. All subjects underwent ocular and retinal examination. Spectral domain optical coherence tomography (SD-OCT) was used to measure the thickness of different layers of the retina at macular and peripapillary regions and at different quadrants. Between groups comparison was performed with P < 0.05 indicating statistical significance. Results: There were 32 eyes in the MS group and 74 eyes in the control group. The MS group was significantly younger than the control group (P < 0.001). The mean ganglion cell complex (GCL++) thickness in superior macular area was 64.1 ± 8.9 μ in the MS group and 71.1 ± 5.9 μ in the control group. The thickness of the RNFL did not statistically differ in each of the quadrants between groups. Despite controlling for age, the macular thickness parameters were significantly thinner in eyes with MS compared to healthy eyes (P < 0.01). Conclusion: The macular ganglion cell complex (mGCC) parameters were significantly reduced in recently diagnosed cases of MS as compared to healthy individuals.


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