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REVIEW ARTICLE
Year : 2019  |  Volume : 67  |  Issue : 6  |  Page : 740-754

Intra-arterial chemotherapy in retinoblastoma – A paradigm change


1 Ocular Oncology Service, HORUS Specialty Eye Care and Prabha Eye Clinic, Bangalore, India; Women's and Children's Hospital, Guangzhou, China
2 Pediatric Ocular Oncology Service, Jules-Gonin Eye Hospital, Lausanne, Switzerland
3 Women's and Children's Hospital, Guangzhou, China
4 Ocular Oncology Service, Center for Sight, Hyderabad, India
5 Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA

Correspondence Address:
Carol L Shields
Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA
USA
Dr. Fairooz P Manjandavida
Ocular Oncology Service, HORUS Specialty Eye Care, Bangalore, Karnataka

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijo.IJO_866_19

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Intra-arterial chemotherapy (IAC), also known as superselective ophthalmic artery chemotherapy or chemosurgery, is currently widely accepted as one of the primary treatment modalities for intraocular retinoblastoma worldwide. Following the introduction of the technique in 1998, IAC has evolved over the past decades to be safer and more effective. Accumulated evidence shows that IAC is more effective in providing eye salvage in group D and E retinoblastoma as compared to conventional systemic intravenous chemotherapy (IVC). In contrast to IVC, IAC has the added benefits of reduced overall treatment duration and minimal systemic toxicity. This review provides a comprehensive update on the history, technique, indications, contraindications, and outcome of IAC. We have also identified the strengths, weaknesses, opportunities and threats (SWOT analysis) of the technique in this review.


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