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Year : 2019  |  Volume : 67  |  Issue : 6  |  Page : 951

Persistent fetal vasculature feeding a retinoblastoma

1 Department of Retina, Narayana Nethralaya, Bengaluru, Karnataka, India
2 Department of Ocular Oncology, Narayana Nethralaya, Bengaluru, Karnataka, India

Date of Web Publication24-May-2019

Correspondence Address:
Dr. Raksha Rao
Department of Ocular Oncology, Narayana Nethralaya, Narayana Health City, Bommasandra, Bengaluru - 560 099, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijo.IJO_353_19

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How to cite this article:
Thirumalesh M B, Rao R, Dudeja G. Persistent fetal vasculature feeding a retinoblastoma. Indian J Ophthalmol 2019;67:951

How to cite this URL:
Thirumalesh M B, Rao R, Dudeja G. Persistent fetal vasculature feeding a retinoblastoma. Indian J Ophthalmol [serial online] 2019 [cited 2020 May 27];67:951. Available from: http://www.ijo.in/text.asp?2019/67/6/951/259039

An 18-month-old male child presented with right eye white reflex for about 2 months. On fundoscopy, the patient was noted to have right eye retinoblastoma. In addition, there was posterior lens capsular opacity [Figure 1]a with a prominent posterior tunica vasculosa lentis (PTVL) dipping into the tumour located at the optic nerve head, confirmed on ultrasound B scan [[Figure 1]a, inset]. After 3 cycles of systemic chemotherapy, the tumour shrinkage resulted in posterior traction by the vasculature causing radial capsular folds [Figure 1]b. PTVL normally starts regressing in the second trimester.[1] In this case, the continued blood supply from these primitive vessels to the retinoblastoma possibly inhibited the regular vascular endothelial growth factor (VEGF)-induced angiogenic mechanisms that take place during vascular regression, leading to persistent fetal vasculature.[2]
Figure 1: Right eye group D retinoblastoma and posterior tunica vasculosa lentis (a) with the persistent fetal vasculature dipping into the tumor (a, inset). Following systemic chemotherapy and tumour shrinkage, there is a star-like capsular appearance from posterior traction (b)

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Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

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Conflicts of interest

There are no conflicts of interest.

  References Top

Goldberg MF. Persistent fetal vasculature (PFV): An integrated interpretation of signs and symptoms associated with persistent hyperplastic primary vitreous (PHPV). LIV Edward Jackson Memorial Lecture. Am J Ophthalmol 1997;124:587-626.  Back to cited text no. 1
Saint-Geniez M, D'Amore P. Development and pathology of the hyaloid, choroidal, and retinal vasculature. Int J Dev Biol 2004;48:1045-58.  Back to cited text no. 2


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