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Year : 2020  |  Volume : 68  |  Issue : 4  |  Page : 637-638

A case of cutaneous candidiasis of upper eyelid in association with facial paralysis

T.C. S.B.U. Tepecik Egitim ve Arastirma Hastanesi, Izmir, Turkey

Date of Submission27-Jul-2019
Date of Acceptance09-Oct-2019
Date of Web Publication16-Mar-2020

Correspondence Address:
Dr. Hasan Aytogan
Güney Mahallesi 1140/1.sok No. 1 35180 Yenisehir, Konak, Izmir
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijo.IJO_1381_19

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Keywords: Brow ptosis, cutaneous candidiasis, facial paralysis, tarsorrhaphy, upper eyelid

How to cite this article:
Aytogan H. A case of cutaneous candidiasis of upper eyelid in association with facial paralysis. Indian J Ophthalmol 2020;68:637-8

How to cite this URL:
Aytogan H. A case of cutaneous candidiasis of upper eyelid in association with facial paralysis. Indian J Ophthalmol [serial online] 2020 [cited 2020 Apr 2];68:637-8. Available from: http://www.ijo.in/text.asp?2020/68/4/637/280707

A 65-year-old woman visited the outpatient eye clinic with a complaint of persistent itching. She had developed facial paralysis 6 years prior and accordingly underwent a lateral tarsorrhaphy five years prior. Left eye lateral tarsorrhaphy had been implemented; however, severe left brow ptosis was notable. Bell's phenomenon was strongly positive. In the primary position, there were no signs of eyelid abnormality [Figure 1]. Complete ophthalmic examination involves assessment of visual acuity, extra-ocular movements, and pupillary movements.[1] However, when the left brow was lifted up, a thick, white, clumpy (cottage-cheese-like) substance with minimal odor was detected [Figure 2]. C. albicans was confirmed on culture. C. albicans can cause infections that range from superficial skin infections to life-threatening systemic infections.[2],[3],[4] The patient had no predisposing immune deficiency diseases such as diabetes mellitus. The white colonies of C. albicans were removed and the eyelid skin was found to be intact. There were no signs of fungal invasion. The patient was prescribed topical oxiconazole nitrate 1% cream (twice per day) and terbinafine hydrochloride 250 mg (once per day). The patient was told to keep the eyelid dry. There were no symptoms of cutaneous candidiasis such as itching and no supporting clinical findings in the first week of follow-up.
Figure 1: Sign of candidiasis observed in the primary position

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Figure 2: Cottage cheese-like substance found when the brow was lifted up

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To date, there have been no reports of cutaneous candidiasis of the upper eyelid, neither as a complication of long-term facial paralysis nor in a healthy individual. This case has demonstrated that cutaneous candidiasis in the eyelid can occur even in an individual with a normal immune system as a complication of long-term facial paralysis. Furthermore, this case highlights the value of complete examination of ocular adnexa and the importance of lifting up the brow to check the deep upper lid in every facial paralysis patient.

Declaration of patient consent

Informed consent was taken in accordance with the principles of Declaration of Helsinki.

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Conflicts of interest

There are no conflicts of interest.

  References Top

Rahman I, Sadiq S. Ophthalmic management of facial nerve palsy: A review. Surv Ophthalmol2007;52:121-44.  Back to cited text no. 1
Mayer FL, Wilson D, Hube B. Candida albicans pathogenicity mechanisms. Virulence2013;4:119-28.  Back to cited text no. 2
Steubesand N, Kiehne K, Brunke G, Pahl R, Reiss K, Herzig KH, et al. The expression of the beta-defensins hBD-2 and hBD-3 is differentially regulated by NF-kappaB and MAPK/AP-1 pathways in an in vitro model of Candida esophagitis. BMC Immunol2009;10:36.  Back to cited text no. 3
Feng Z, Jiang B, Chandra J, Ghannoum M, Nelson S, Weinberg A. Human beta-defensins: Differential activity against candidal species and regulation by Candida albicans. J Dent Res2005;84:445-50.  Back to cited text no. 4


  [Figure 1], [Figure 2]


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