|Year : 2020 | Volume
| Issue : 5 | Page : 917
Abnormal corneal pigmentation by psychotropic drugs
Savleen Kaur, Surbhi Khurana, Jagat Ram
Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India
|Date of Web Publication||20-Apr-2020|
Dr. Jagat Ram
Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Kaur S, Khurana S, Ram J. Abnormal corneal pigmentation by psychotropic drugs. Indian J Ophthalmol 2020;68:917
A 23-year male presented for a routine ophthalmic examination, with visual acuity 20/20 OU. Slit lamp examination revealed bilateral inferior corneal pigmentation, involving the anterior cornea, at the level of epidermis and anterior stroma [Figure 1]. Posterior segment examination was unremarkable. There was history of ingestion of desvenlaxafine 50 mg and clonazepam 0.5 mg OD since last 2 years for depression. Desvenlaxafine and clonazepam are oral selective serotonin and norepinephrine reuptake inhibitor (SSRI) and benzodiazepine, respectively. Many drugs can present with corneal pigmentation,,, but such pigmentation with SSRIs has not been reported. With increasing dosage, retinal, and/or lenticular pigmentation can occur causing visual impairment, hence warranting periodic ocular examination in such patients.
|Figure 1: (a) Diffuse illumination showing inferior corneal pigmentation from 4 o' clock to 8 o' clock position. (b) Slit view showing inferior corneal pigmentation, from 4 o' clock to 8 o' clock position, in anterior cornea, at the level of epidermis and anterior stroma (arrow)|
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The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
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