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OPHTHALMIC IMAGE
Year : 2020  |  Volume : 68  |  Issue : 8  |  Page : 1666

Recurrent corneal erosion image by scanning electron microscopy


Hospital Clinic of Barcelona, Sabino de Arana 1, Barcelona, Spain

Date of Web Publication24-Jul-2020

Correspondence Address:
Dr. Carlos Rocha de Lossada
Hospital Clinic of Barcelona, Sabino de Arana 1, Barcelona
Spain
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijo.IJO_2282_19

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How to cite this article:
Peraza Nieves J, Rocha de Lossada C, Sabater Cruz N, Torras Sanvicens J. Recurrent corneal erosion image by scanning electron microscopy. Indian J Ophthalmol 2020;68:1666

How to cite this URL:
Peraza Nieves J, Rocha de Lossada C, Sabater Cruz N, Torras Sanvicens J. Recurrent corneal erosion image by scanning electron microscopy. Indian J Ophthalmol [serial online] 2020 [cited 2020 Aug 12];68:1666. Available from: http://www.ijo.in/text.asp?2020/68/8/1666/290434



Corneal epithelial basement membrane (EBM) is positioned between basal surface of the epithelial cells and on top of the Bowman layer (BL). It consists of 0.33 μm multilayered extracellular matrix of collagens, laminins, heparan sulfate proteoglycans, and nidogens.[1]

Recurrent corneal erosions (RCE) are characterized by sudden onset of eye pain typically in eyes that have had suffered from a previous sharp trauma or patients suffering from some corneal dystrophy.[2],[3] The trauma induces a lack of attachment of cell-to-cell or cell-to-matrix causing a disruption.[4]

We simulated a sharp trauma with a 30 G needle at the epithelium of a corneoscleral-rim from a donor cornea and analyzed it using scanning electron microscopy [Figure 1] to show how RCE appear and to better understand the anatomical disruption and attachment of the EBM to BL to search new therapeutic targets.[5]
Figure 1: Yellow arrows: epithelial basement membrane, red arrow: Bowmann layer, blue arrow: sub-basal nerve foramen

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Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Torricelli AA, Singh V, Santhiago MR, Wilson SE. The corneal epithelial basement membrane: Structure, function, and disease. Invest Ophthalmol VisSci 2013;54:6390-400.  Back to cited text no. 1
    
2.
Ewald M, Hammersmith KM. Review of diagnosis and management of recurrent erosion syndrome. Curr Opin Ophthalmol 2009;20:287-91.  Back to cited text no. 2
    
3.
Diez-Feijóo E, Grau AE, Abusleme EI, Durán JA. Clinical presentation and causes of recurrent corneal erosion syndrome: Review of 100 patients. Cornea2014;33:571-5.  Back to cited text no. 3
    
4.
Miller DD, Hasan SA, Simmons NL, Stewart MW. Recurrent corneal erosion: A comprehensive review. Clin Ophthalmol 2019;13:325-35.  Back to cited text no. 4
    
5.
Aifa A, Gueudry J, Portmann A, Delcampe A, Muraine M. Topical treatment with a new matrix therapy agent (RGTA) for the treatment of corneal neurotrophic ulcers. Invest Ophthalmol Vis Sci 2012;53:8181-5.  Back to cited text no. 5
    


    Figures

  [Figure 1]



 

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