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OPHTHALMIC IMAGE |
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Year : 2020 | Volume
: 68
| Issue : 8 | Page : 1666 |
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Recurrent corneal erosion image by scanning electron microscopy
Jorge Peraza Nieves, Carlos Rocha de Lossada, Noelia Sabater Cruz, Josep Torras Sanvicens
Hospital Clinic of Barcelona, Sabino de Arana 1, Barcelona, Spain
Date of Web Publication | 24-Jul-2020 |
Correspondence Address: Dr. Carlos Rocha de Lossada Hospital Clinic of Barcelona, Sabino de Arana 1, Barcelona Spain
Source of Support: None, Conflict of Interest: None | Check |
DOI: 10.4103/ijo.IJO_2282_19
How to cite this article: Peraza Nieves J, Rocha de Lossada C, Sabater Cruz N, Torras Sanvicens J. Recurrent corneal erosion image by scanning electron microscopy. Indian J Ophthalmol 2020;68:1666 |
Corneal epithelial basement membrane (EBM) is positioned between basal surface of the epithelial cells and on top of the Bowman layer (BL). It consists of 0.33 μm multilayered extracellular matrix of collagens, laminins, heparan sulfate proteoglycans, and nidogens.[1]
Recurrent corneal erosions (RCE) are characterized by sudden onset of eye pain typically in eyes that have had suffered from a previous sharp trauma or patients suffering from some corneal dystrophy.[2],[3] The trauma induces a lack of attachment of cell-to-cell or cell-to-matrix causing a disruption.[4]
We simulated a sharp trauma with a 30 G needle at the epithelium of a corneoscleral-rim from a donor cornea and analyzed it using scanning electron microscopy [Figure 1] to show how RCE appear and to better understand the anatomical disruption and attachment of the EBM to BL to search new therapeutic targets.[5] | Figure 1: Yellow arrows: epithelial basement membrane, red arrow: Bowmann layer, blue arrow: sub-basal nerve foramen
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Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
References | | |
1. | Torricelli AA, Singh V, Santhiago MR, Wilson SE. The corneal epithelial basement membrane: Structure, function, and disease. Invest Ophthalmol VisSci 2013;54:6390-400. |
2. | Ewald M, Hammersmith KM. Review of diagnosis and management of recurrent erosion syndrome. Curr Opin Ophthalmol 2009;20:287-91. |
3. | Diez-Feijóo E, Grau AE, Abusleme EI, Durán JA. Clinical presentation and causes of recurrent corneal erosion syndrome: Review of 100 patients. Cornea2014;33:571-5. |
4. | Miller DD, Hasan SA, Simmons NL, Stewart MW. Recurrent corneal erosion: A comprehensive review. Clin Ophthalmol 2019;13:325-35. |
5. | Aifa A, Gueudry J, Portmann A, Delcampe A, Muraine M. Topical treatment with a new matrix therapy agent (RGTA) for the treatment of corneal neurotrophic ulcers. Invest Ophthalmol Vis Sci 2012;53:8181-5. |
[Figure 1]
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