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Year : 2020  |  Volume : 68  |  Issue : 9  |  Page : 1852-1862

Systemic immunosuppressive therapies for uveitis in developing countries

1 L V Prasad Eye Institute, Hyderabad, Telangana, India
2 Byers Eye Institute, Palo Alto, CA, USA
3 Sir Ganga Ram Hospital, New Delhi, India
4 Aravind Eye Institute, Salem, Tamil Nadu, India
5 Save Sight Institute, Sydney NSW, Australia, USA
6 Dr Shroff Charity Eye Hospital, New Delhi, India

Correspondence Address:
Dr. Mudit Tyagi
L V Prasad Eye Institute, Banjara Hills Road No 2, Hyderabad, Telangana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijo.IJO_1548_20

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There are multiple approaches to inhibit inflammatory molecules and pathways in noninfectious uveitis. The cornerstone of local and systemic anti-inflammatory treatment is corticosteroid therapy. Corticosteroids remain the most potent and efficacious drugs for treating intraocular inflammation. However, their long-term use is limited by their medium- and long-term side effects, which are a major concern. The approach taken to limit corticosteroid side effects is to introduce steroid-sparing agents that suppress the inflammatory pathways and immune response differently than corticosteroids. There are several classes of such drugs that are affordable, effective, and generally well-tolerated. Relatively recently, an increasing range of biologic agents has become available to treat intraocular inflammation. However, the relatively expensive cost of these therapies limits their use in the developing world. This systemic review aimst to discuss the use of corticosteroids and different immunosuppressive regimens in the management of various uveitides.

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