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Year : 2020  |  Volume : 68  |  Issue : 9  |  Page : 1986-1988

Worsening of posterior scleritis and orbital pseudotumor in a patient with granulomatosis polyangiitis with rituximab-A case report

1 Department of Uveitis and Ocular Inflammation, Vittala International Institute of Ophthalmology, Prabha Eye Clinic and Research Centre, Bengaluru, Karnataka, India
2 Department of Rheumatology, Vikram Hospitals, Bengaluru, Karnataka, India

Correspondence Address:
Dr. Kalpana Babu
504, 40th Cross, Jayanagar 8th Block, Bengaluru - 560 070, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijo.IJO_1644_20

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We report a case of exacerbation of posterior scleritis and orbital pseudotumor in a patient with granulomatosis polyangiitis, with initial rituximab infusion. Modifications in rituximab protocols including reduction in maintenance dose for subsequent infusions with increase in premedication dose of intravenous methyl prednisolone may be useful to prevent periinfusional flares. In this case report, we highlight a rare occurrence and modification in rituximab protocol to prevent post-infusional flare of inflammation.

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