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Year : 2020  |  Volume : 68  |  Issue : 9  |  Page : 2007-2009

Uveitis, retinal vasculitis, and loss of accommodation as sole manifestations of demyelinating disease: A case report

1 Department of Ophthalmogy, Vittala International Institute of Ophthalmology and Prabha Eye Clinic and Research Center, Bengaluru, Karnataka, India
2 Department of Ophthalmogy, Vittala International Institute of Ophthalmology and Prabha Eye Clinic and Research CenterBengaluru, Karnataka; Department of Clinical Research, Manipal Academy of Higher Education, Manipal; Department of Clinical Research, Institute of Bioinformatics, Bangalore, India

Correspondence Address:
Dr. Kalpana Babu
Prabha Eye Clinic and Research Centre, 504, 40th Cross, Jayanagar 8th block, Bengaluru - 560 070, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijo.IJO_2017_19

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In this report we describe nongranulomatous uveitis followed by bilateral retinal vasculitis and much later by the loss of accommodation as initial presentations of demyelinating disease in a 42-year-old female with no other neurologic manifestations. The absence of demyelinating plaques in the initial magneric resonance imaging (MRI) (orbit and cranium) and its occurrence 2 years later, have been described as “lesions appearing with time”. Extensive laboratory investigations ruled out infections, systemic vasculitis, and connective tissue disorders. Due to the presence of oligoclonal bands in both cerebrospinal fluid (CSF) and serum, absence of antiaquaporin-4, antimyelin-oligodendrocyte glycoprotein immunoglobulin G (IgG) antibodies, and negative vasculitis profile, the exact cause of demyelination (multiple sclerosis/vasculitis related) could not be ascertained. She has currently received 2 cycles of rituximab and at the last follow-up did not show any recurrences.

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