RT - Journal TY - JOUR A1 - Thomas, Ravi A1 - Jacob, Aby A1 - Raju, Renu A1 - Gieser, Stephen A1 - Sen, Subir T1 - Incidence of complications following 5-fluorouracil with trabeculectomies YR - 1993/10/1 JF - Indian Journal of Ophthalmology JO - Indian J Ophthalmol SP - 185 OP - 186 VO - 41 IS - 4 UL - https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=1993;volume=41;issue=4;spage=185;epage=186;aulast=Thomas;t=5 N2 - To investigate the incidence of complications reportedly caused by the use of 5-fluorouracil (5-FU) in glaucoma filtering surgery, we performed trabeculectomy with 5-FU on 57 eyes of 56 patients with advanced glaucoma. The mean preoperative intraocular pressure was 34.8 mm Hg. The most frequent complication encountered was superficial punctate keratopathy (26%), followed by shallowing of the anterior chamber (12%), choroidal detachment (9%), and flap retraction (7%). We, however, did not encounter any cases of confluent corneal epithelial defect, subepithelial scarring, or striate melanokeratosis which are usually described with the use of 5-FU. With a mean follow-up of 7.1 months, an intraocular pressure less than 16 mm Hg without hypotensive therapy were achieved in 73.7% of cases, and less than 21 mm Hg without hypotensive therapy in 86%. Considering the low incidence of complications and the high success rate, we recommend the use of 5-FU in routine glaucoma filtering surgery ER -