%A Lamba, P %A Pandey, P %A Raina, U %A Krishna, V %T Short-term results of initial trabeculectomy with intraoperative or postoperative 5-fluorouracil for primary glaucomas %9 Original Article %D 1997 %J Indian Journal of Ophthalmology %P 173-176 %V 45 %N 3 %U https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=1997;volume=45;issue=3;spage=173;epage=176;aulast=Lamba %8 July 1, 1997 %X Thirty-three eyes of 33 patients were prospectively evaluated to study the short term efficacy, safety, and overall surgical outcome of initial trabeculectomy for primary glaucomas with adjunctive intraoperative or postoperative 5-Fluorouracil (5-FU) use. Twelve eyes serving as controls underwent trabeculectomy without adjunctive antimetabolites. Eleven eyes received intraoperative 5-FU, while 10 eyes received subconjunctival 5-FU postoperatively. Intraocular pressure (IOP) was maintained below 22 mmHg at 3 months of follow up in 90.9% and 80% of patients in the intraoperative and postoperative 5-FU groups, respectively, without use of additional antiglaucoma medications, whereas 66.7% of the patients in the control group achieved similar IOP levels. Hypotony (IOP < 6 mmHg) was seen more commonly after intraoperative 5-FU (27.3%). Corneal epithelial defects were seen exclusively in the postoperative 5-FU group (40%). The use of intraoperative 5-FU exclusively as a mode of antimetabolites delivery seems an acceptable alternative to enhance success rates of trabeculectomy for the primary glaucomas. %0 Journal Article %I Wolters Kluwer Medknow Publications %@ 0301-4738