TY - JOUR A1 - Singh, Vijay A1 - Tripathi, P T1 - Gene therapy in ocular diseases Y1 - 2002/7/1 JF - Indian Journal of Ophthalmology JO - Indian J Ophthalmol SP - 173 EP - 181 VL - 50 IS - 3 UR - https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=2002;volume=50;issue=3;spage=173;epage=181;aulast=Singh N2 - Gene therapy is a novel form of drug delivery that enlists the synthetic machinery of the patient's cells to produce a therapeutic agent. Genes may be delivered into cells in vitro or in vivo utilising viral or non-viral vectors. Recent technical advances have led to the demonstration of the molecular basis of various ocular diseases. Ocular disorders with the greatest potential for benefit of gene therapy include hereditary diseases such as retinitis pigmentosa, tumours such as retinoblastoma or melanoma, and acquired proliferative and neovascular retinal disorders. Gene transfer into ocular tissues has been demonstrated with growing functional success and may develop into a new therapeutic tool for clinical ophthalmology in future. ER -