TY - JOUR A1 - Sangwan, Virender A1 - Burman, Sanghamitra A1 - Tejwani, Sushma A1 - Mahesh, Sankaranarayana A1 - Murthy, Ramesh T1 - Amniotic membrane transplantation: A review of current indications in the management of ophthalmic disorders Y1 - 2007/7/1 JF - Indian Journal of Ophthalmology JO - Indian J Ophthalmol SP - 251 EP - 260 VL - 55 IS - 4 UR - https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=2007;volume=55;issue=4;spage=251;epage=260;aulast=Sangwan DO - 10.4103/0301-4738.33036 N2 - Amniotic membrane transplantation is currently being used for a continuously widening spectrum of ophthalmic indications. It has gained widespread attention as an effective method of reconstruction of the ocular surface. Amniotic membrane has a unique combination of properties, including the facilitation of migration of epithelial cells, the reinforcement of basal cellular adhesion and the encouragement of epithelial differentiation. Its ability to modulate stromal scarring and its anti-inflammatory activity has led to its use in the treatment of ocular surface pathology as well as an adjunct to limbal stem cell grafts. Amniotic membrane transplantation has been used for reconstruction of the corneal surface in the setting of persistent epithelial defects, partial limbal stem cell deficiency, bullous keratopathy and corneoscleral ulcers. It has also been used in conjunction with limbal stem cell transplantation for total limbal stem cell deficiency. Amniotic membrane grafts have been effectively used as a conjunctival substitute for reconstruction of conjunctival defects following removal of pterygia, conjunctival lesions and symblephara. More recently, amniotic membrane has been used as a substrate for ex vivo cultivation of limbal, corneal and conjunctival epithelial cells. This article reviews the current literature on the applications of amniotic membrane transplantation and its outcome in various ophthalmic conditions. ER -