TY - JOUR A1 - Deniz, Nurettin A1 - Aydemir, Orhan A1 - Güler, Mete A1 - Akpolat, Nusret A1 - Kizirgil, Ahmet T1 - Comparison of efficiency of intravitreal ceftazidime and intravitreal cefepime in the treatment of experimental Pseudomonas aeruginosa endophthalmitis Y1 - 2013/9/1 JF - Indian Journal of Ophthalmology JO - Indian J Ophthalmol SP - 525 EP - 527 VL - 61 IS - 9 UR - https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=2013;volume=61;issue=9;spage=525;epage=527;aulast=Deniz DO - 10.4103/0301-4738.119457 N2 - In this study, we evaluated the efficiency of cefepime in the treatment of experimental Pseudomonas aeruginosa endophthalmitis. We compared the findings with the standard dose of ceftazidime (1 mg/0.1 ml). Thirty-six New-Zealand White rabbits were divided into 6 equal groups and were treated with different methods (Group 1 = sham, Group 2 = 0.5 mg/0.1 ml cefepime, Group 3 = 1 mg/0.1 ml cefepime, Group 4 = 2 mg/0.1 ml cefepime, Group 5 = 1 mg/0.1 ml ceftazidime, Group 6 = control). The eyes of rabbits in each group were examined clinically on 1 st , 3 rd , and 6 th day of the experiment. At 6 th day, 0.1 ml vitreous humor aspirates were obtained and plated for quantification on the blood agar and the results were expressed as colony-forming unit/ml. Subsequently, the eyeballs were enucleated and the histopathological evaluation was performed. Our findings denoted beneficial effects of cefepime in treatment groups (especially, in Groups 3 and 4). Intravitreal cefepime may be an alternative drug in the treatment of P. aeruginosa endophthalmitis. ER -