TY - JOUR A1 - Nair, Akshay A1 - Kaliki, Swathi A1 - Mishra, Dilip A1 - Reddy, Vijay A1 - Naik, Milind T1 - Neoadjuvant chemotherapy for invasive squamous cell carcinoma of the conjunctiva: A case report Y1 - 2015//1 JF - Indian Journal of Ophthalmology JO - Indian J Ophthalmol SP - 927 EP - 929 VL - 63 IS - 12 UR - https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=2015;volume=63;issue=12;spage=927;epage=929;aulast=Nair DO - 10.4103/0301-4738.176026 N2 - A 40-year-old male presented with an orbital extension of conjunctival squamous cell carcinoma (SCC). The orbital mass was seen protruding outward from the left palpebral fissure overhanging the lower eyelid, completely obscuring the globe and lower lid. The patient gave a history of excision biopsy, which was histopathologically diagnosed as ocular surface squamous neoplasia. He also gave a history of tumor recurrence, which gradually progressed to assume the form of the presently visible orbital mass. Computed tomography of the orbits showed the mass extending into the left orbit causing superior displacement of the globe. After a negative locoregional and systemic metastatic screening, neoadjuvant intravenous systemic chemotherapy with cisplatin and 5-fluorouracil were initiated in an attempt to reduce the size of the tumor. Three cycles of tri-weekly chemotherapy resulted in a significant reduction of the orbital tumor size with the globe and the lower lid being visible, thus making a lid-sparing orbital exenteration possible. The patient subsequently underwent an orbital exenteration and at 6-month follow-up, the patient was free from local and regional disease. To our knowledge, this is the first reported case where systemic neoadjuvant chemotherapy has been used to reduce the size of invasive SCC with orbital extension, thereby permitting a lid-sparing orbital exenteration. ER -