TY - JOUR A1 - Jagadeesan, Madhavan A1 - Khetan, Vikas A1 - Mallipatna, Ashwin T1 - Genetic perspective of retinoblastoma: From present to future Y1 - 2016/5/1 JF - Indian Journal of Ophthalmology JO - Indian J Ophthalmol SP - 332 EP - 336 VL - 64 IS - 5 UR - https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=2016;volume=64;issue=5;spage=332;epage=336;aulast=Jagadeesan DO - 10.4103/0301-4738.185585 N2 - Retinoblastoma (RB) is the most common malignant intraocular tumor in children. In the last decade, basic research has led to a better understanding of events after two hits in RB susceptibility gene (RB1), molecular mechanism of tumor growth, the cell of origin of RB, etc. This would pave way to identify biomarkers and molecular targeted therapy for better treatment option in the future. Furthermore, improvement in molecular techniques has led to enhanced diagnostic methods for early diagnosis, genetic counseling, and prevention of the disease. This review will help to understand the essence of basic research work conducted in recent times and its implication in the management of RB in the future. ER -