author = {Bharathi Devi, Subramaniam. and Coral, Karunakaran. and Gayathree, Karthikeyan. and Bharathselvi, Muthuvel. and Sivasankar, Shanmuganathan. and Biswas, Jyotirmoy. and Rishi, Pukhraj. and Natarajan, Sundaram. and Badrinath, Sengamedu. and Angayarkanni, Narayanasamy.}, title = {{Case report on two diabetic donor eyes with no retinopathy: Clinicopathological and molecular studies}}, journal ={Indian Journal of Ophthalmology}, volume ={67}, number ={10}, pages = {1762-1765}, doi = {10.4103/ijo.IJO_400_19}, year = {2019}, abstract ={ We were intrigued to analyze donor eyes of two individuals without retinopathy even after 40 years of type 2 diabetes mellitus. Targeted molecular factors associated with angiogenesis and the key antioxidant enzymes in retinal tissue were analyzed. Accordingly PEDF, Adiponectin and Paraoxonase 2 showed augmented mRNA expression in both the retina with no significant change in VEGF expression. Vitreous showed increased PEDF protein in donor 1 and Adiponectin in donor 2 with no change in VEGF protein. This study highlights the profile of specific molecular factors that contribute to the non-development of diabetic retinopathy changes in these individuals. }, URL ={https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=2019;volume=67;issue=10;spage=1762;epage=1765;aulast=Bharathi;t=6}, eprint ={https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=2019;volume=67;issue=10;spage=1762;epage=1765;aulast=Bharathi;t=6} }