Indian Journal of Ophthalmology

: 1979  |  Volume : 27  |  Issue : 4  |  Page : 49--50

Glucose 6-Phosphate dehydrogenase deficiency in congenital and senile cataracts

UC Behera, G Devdas 
 M.K.C.G. Medical College Berhampur, Orissa, India

Correspondence Address:
U C Behera
Professor M.K.C.G. Medical College, Berhampur, Orissa

How to cite this article:
Behera U C, Devdas G. Glucose 6-Phosphate dehydrogenase deficiency in congenital and senile cataracts.Indian J Ophthalmol 1979;27:49-50

How to cite this URL:
Behera U C, Devdas G. Glucose 6-Phosphate dehydrogenase deficiency in congenital and senile cataracts. Indian J Ophthalmol [serial online] 1979 [cited 2020 Sep 19 ];27:49-50
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Full Text

Glucose-6-Phosphate dehydrogenase (G6PD) is recognised as an important enzyme in glucose metabolism and its deficiency is commonly associated with a number of hereditary disor­ders. It is estimated that at least 100 million of total population of different ethenic groups in the world suffer from this deficiency. The incidence varies from 2 to 20%. A recent survey in southern Orissa showed an incidence of 6.1%. There are some evidences to suggest that G6PD deficiency may be associated with cataractous changes in the lens. The present study aims at investigating association of eryth­rocytic G6PD deficiency with various types of cataracts.

 Materials and Methods

It includes 25 cases, each of congenital cataract, senile immature cataract, senile mature cataract, normal lens, and 10 cases of traumatic cataract and 15 hyper­mature cataract.


The number of patients in each age group were fairly comparable. The incidence of G6PD deficiency was highest in 1-10 age group (63%) and the incidence declined with age. The sex difference was not significant (Male: 16.6%; Female: 20.7%).

Family History

In the persent study 3 out of 21 cases of congenital cataract with G6PD deficiency index had positive family history regarding incidence of congenital cataract occur­ing in other members of his family or near relations.

Twenty one of 25 cases of congenital cataract had G6PD deficiency. There seems to be a significant association. Of the 4 cases without erythrocytic G6PD deficiency one had gastro-intestinal disorder and an­other had serum V.D.R.L. positive. Of the 21 cases of congenital cataract with G6PD deficiency, 7 had associa­ted disorders: coloboma iris-2 cases, Marfan's Syndro­me-2 cases, microphthalmos-I case, skull deformities -1 case, hepatosplenomegaly-1 case.

History of medication prior to noticing cataract:

In the present study 4 out of 25 cases gave the history of taking medicines like salicylates, sulfaroxazole and chloroquin group of drugs prior to their noticing cataract All had erythrocytic G6PD deficiency.


In conclusion it can be stated that in the deficient state of G6PD, there seems to occur some important derangement of lens metabolism, probably accumulation of peroxides, resulting in cataract formation.