Indian Journal of Ophthalmology

ORIGINAL ARTICLE
Year
: 1993  |  Volume : 41  |  Issue : 4  |  Page : 185--186

Incidence of complications following 5-fluorouracil with trabeculectomies


Ravi Thomas, Aby Jacob, Renu Raju, Stephen C Gieser, Subir Sen 
 Department of Ophthalmology, Christian Medical College, Vellore, India

Correspondence Address:
Ravi Thomas
Schell Eye Hospital, Vellore, Tamil Nadu 632 001
India

To investigate the incidence of complications reportedly caused by the use of 5-fluorouracil (5-FU) in glaucoma filtering surgery, we performed trabeculectomy with 5-FU on 57 eyes of 56 patients with advanced glaucoma. The mean preoperative intraocular pressure was 34.8 mm Hg. The most frequent complication encountered was superficial punctate keratopathy (26%), followed by shallowing of the anterior chamber (12%), choroidal detachment (9%), and flap retraction (7%). We, however, did not encounter any cases of confluent corneal epithelial defect, subepithelial scarring, or striate melanokeratosis which are usually described with the use of 5-FU. With a mean follow-up of 7.1 months, an intraocular pressure less than 16 mm Hg without hypotensive therapy were achieved in 73.7% of cases, and less than 21 mm Hg without hypotensive therapy in 86%. Considering the low incidence of complications and the high success rate, we recommend the use of 5-FU in routine glaucoma filtering surgery


How to cite this article:
Thomas R, Jacob A, Raju R, Gieser SC, Sen S. Incidence of complications following 5-fluorouracil with trabeculectomies.Indian J Ophthalmol 1993;41:185-186


How to cite this URL:
Thomas R, Jacob A, Raju R, Gieser SC, Sen S. Incidence of complications following 5-fluorouracil with trabeculectomies. Indian J Ophthalmol [serial online] 1993 [cited 2019 Sep 19 ];41:185-186
Available from: http://www.ijo.in/article.asp?issn=0301-4738;year=1993;volume=41;issue=4;spage=185;epage=186;aulast=Thomas;type=0