Indian Journal of Ophthalmology

ORIGINAL ARTICLE
Year
: 1997  |  Volume : 45  |  Issue : 3  |  Page : 173--176

Short-term results of initial trabeculectomy with intraoperative or postoperative 5-fluorouracil for primary glaucomas


PA Lamba, PK Pandey, UK Raina, V Krishna 
 Maulana Azad Medical College, New Delhi, India

Correspondence Address:
P A Lamba
Maulana Azad Medical College, New Delhi
India

Thirty-three eyes of 33 patients were prospectively evaluated to study the short term efficacy, safety, and overall surgical outcome of initial trabeculectomy for primary glaucomas with adjunctive intraoperative or postoperative 5-Fluorouracil (5-FU) use. Twelve eyes serving as controls underwent trabeculectomy without adjunctive antimetabolites. Eleven eyes received intraoperative 5-FU, while 10 eyes received subconjunctival 5-FU postoperatively. Intraocular pressure (IOP) was maintained below 22 mmHg at 3 months of follow up in 90.9% and 80% of patients in the intraoperative and postoperative 5-FU groups, respectively, without use of additional antiglaucoma medications, whereas 66.7% of the patients in the control group achieved similar IOP levels. Hypotony (IOP < 6 mmHg) was seen more commonly after intraoperative 5-FU (27.3%). Corneal epithelial defects were seen exclusively in the postoperative 5-FU group (40%). The use of intraoperative 5-FU exclusively as a mode of antimetabolites delivery seems an acceptable alternative to enhance success rates of trabeculectomy for the primary glaucomas.


How to cite this article:
Lamba P A, Pandey P K, Raina U K, Krishna V. Short-term results of initial trabeculectomy with intraoperative or postoperative 5-fluorouracil for primary glaucomas.Indian J Ophthalmol 1997;45:173-176


How to cite this URL:
Lamba P A, Pandey P K, Raina U K, Krishna V. Short-term results of initial trabeculectomy with intraoperative or postoperative 5-fluorouracil for primary glaucomas. Indian J Ophthalmol [serial online] 1997 [cited 2020 Apr 10 ];45:173-176
Available from: http://www.ijo.in/article.asp?issn=0301-4738;year=1997;volume=45;issue=3;spage=173;epage=176;aulast=Lamba;type=0