Indian Journal of Ophthalmology

BRIEF COMMUNICATION
Year
: 2011  |  Volume : 59  |  Issue : 3  |  Page : 242--246

Photodynamic monotherapy or combination treatment with intravitreal triamcinolone acetonide, bevacizumab or ranibizumab for choroidal neovascularization associated with pathological myopia


Pukhraj Rishi, Ekta Rishi, Anusha Venkataraman, Lingam Gopal, Tarun Sharma, Muna Bhende, Dhanashree Ratra, Pratik Ranjan Sen, Parveen Sen 
 Shri Bhagwan Mahavir Vitreo Retinal Services, Sankara Nethralaya, 18 College Road, Chennai - 600 006, Tamil Nadu, India

Correspondence Address:
Pukhraj Rishi
Shri Bhagwan Mahavir Vitreo Retinal Services, Sankara Nethralaya, 18 College Road, Chennai - 600 006, Tamil Nadu
India

This retrospective, interventional case series analyses treatment outcomes in eyes with choroidal neovascularization (CNV) secondary to pathological myopia, managed with photodynamic therapy, (PDT), (Group 1, N = 11), PDT and intravitreal triamcinolone acetonide (4 mg/0.1ml) (Group 2, N = 3), PDT and intravitreal anti-vascular endothelial growth factor (anti-VEGF) bevacizumab 1.25 mg/0.05 ml, ranibizumab 0.5 mg/0.05 ml and reduced-fluence PDT and intravitreal ranibizumab 0.5 mg/0.05 ml (Group 3, N=12). All the patients underwent PDT. Intravitreal injections were repeated as required. SPSS 14 software was used to evaluate the data. Wilcoxon signed ranks test was used to evaluate pre- and post-treatment vision. The Kruskal-Wallis test was used for comparison between the groups. All the groups were statistically comparable. All the eyes showed complete regression of CNV, with a minimum follow-up of six months. All groups had visual improvement; significantly in Group 3 ( p = 0.003). Combination PDT with anti-VEGF agents appeared to be efficacious in eyes with myopic CNV. However, a larger study with a longer follow-up is required to validate these results.


How to cite this article:
Rishi P, Rishi E, Venkataraman A, Gopal L, Sharma T, Bhende M, Ratra D, Sen PR, Sen P. Photodynamic monotherapy or combination treatment with intravitreal triamcinolone acetonide, bevacizumab or ranibizumab for choroidal neovascularization associated with pathological myopia.Indian J Ophthalmol 2011;59:242-246


How to cite this URL:
Rishi P, Rishi E, Venkataraman A, Gopal L, Sharma T, Bhende M, Ratra D, Sen PR, Sen P. Photodynamic monotherapy or combination treatment with intravitreal triamcinolone acetonide, bevacizumab or ranibizumab for choroidal neovascularization associated with pathological myopia. Indian J Ophthalmol [serial online] 2011 [cited 2024 Mar 29 ];59:242-246
Available from: https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=2011;volume=59;issue=3;spage=242;epage=246;aulast=Rishi;type=0