Indian Journal of Ophthalmology

LETTER TO THE EDITOR
Year
: 2012  |  Volume : 60  |  Issue : 2  |  Page : 164-

DNA chip-assisted diagnosis for ocular toxoplasmosis: A comment


Viroj Wiwanitkit 
 Wiwanitkit House, Bangkhae, Bangkok, Thailand

Correspondence Address:
Viroj Wiwanitkit
Wiwanitkit House, Bangkhae, Bangkok 10160
Thailand




How to cite this article:
Wiwanitkit V. DNA chip-assisted diagnosis for ocular toxoplasmosis: A comment.Indian J Ophthalmol 2012;60:164-164


How to cite this URL:
Wiwanitkit V. DNA chip-assisted diagnosis for ocular toxoplasmosis: A comment. Indian J Ophthalmol [serial online] 2012 [cited 2020 Jul 8 ];60:164-164
Available from: http://www.ijo.in/text.asp?2012/60/2/164/94071


Full Text

Dear Editor,

I read the recent publication on DNA chip-assisted diagnosis for ocular toxoplasmosis with a great interest. [1] I accept that this report might imply the usefulness of DNA-chip technology in diagnosis of toxoplasmosis. However, there are some concerns in laboratory medicine for this report. First, although Basu et al., mentioned that validation of the DNA chip was already done there is no data on its diagnostic properties (sensitivities, specificity, accuracy, predictive value, etc.). Second, although the use of DNA chip helps provide diagnosis on multiple foci at a single time it can increase the error in the diagnosis. [2] Finally, I would like to conclude that the complete data on the properties as well as cost effectiveness of the DNA-chip approach is still required before implementation of this test for routine usage.

References

1Basu S, Sharma S, Kar S, Das T. DNA chip-assisted diagnosis of a previously unknown etiology of intermediate uveitis-Toxoplasma gondii. Indian J Ophthalmol 2010;58:535-7.
2Pounds SB. Estimation and control of multiple testing error rates for microarray studies. Brief Bioinform 2006;7:25-36.