Indian Journal of Ophthalmology

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 62  |  Issue : 2  |  Page : 219--223

Clinicopathological correlation of parapapillary atrophy in monkeys with experimental glaucoma and temporary central retinal artery occlusion


Jost B Jonas1, Sohan S Hayreh2, Yong Tao1 
1 Department of Ophthalmology and Eye Hospital, and the Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Mannheim, Germany
2 Department of Ophthalmology and Visual Sciences, College of Medicine, University of Iowa, Iowa City, Iowa, USA

Correspondence Address:
Jost B Jonas
Department of Ophthalmology and Eye Hospital, and the Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Universitäts-Augenklinik, Theodor-Kutzer-Ufer, Mannheim
Germany

Objective: To investigate the clinicopathological correlation of parapapillary atrophy. Materials and Methods: The study included 16 eyes of rhesus monkeys (Macaca mulatta) - 4 eyes with experimental glaucoma, 11 eyes after experimental temporary occlusion of the central retinal artery, and 1 normal eye. On histological sections, we measured zones with different histological characteristics.On fundus photographs, alpha zone and beta zone of parapapillary atrophy were measured and correlated with the histological data. Results: The size of the clinical alpha zone of parapapillary atrophy was significantly correlated with the size of the histological region with irregularities of the retinal pigment epithelium (P = 0.05; correlation coefficient r = 0.49) and with the size of the histological region with a decreased density of retinal photoreceptors (P = 0.01; r = 0.60). The size of clinical beta zone of parapapillary atrophy significantly correlated with the size of the histological region with complete loss of the retinal pigment epithelium (P <0.001; r = 0.91), with the size of the histological zone with a complete loss of photoreceptors (P <0.001; r = 0.81), and with the size of the histological zone with a closed choriocapillaris (P <0.001; r = 0.89). Conclusions: The clinically seen alpha zone of parapapillary atrophy correlates with histological parapapillary irregularities of the retinal pigment epithelium and decreased density of retinal photoreceptors. The clinically seen beta zone of parapapillary atrophy correlates with histological complete loss of the retinal pigment epithelium and of the photoreceptors, and a closure of the choriocapillaris.


How to cite this article:
Jonas JB, Hayreh SS, Tao Y. Clinicopathological correlation of parapapillary atrophy in monkeys with experimental glaucoma and temporary central retinal artery occlusion.Indian J Ophthalmol 2014;62:219-223


How to cite this URL:
Jonas JB, Hayreh SS, Tao Y. Clinicopathological correlation of parapapillary atrophy in monkeys with experimental glaucoma and temporary central retinal artery occlusion. Indian J Ophthalmol [serial online] 2014 [cited 2019 Nov 17 ];62:219-223
Available from: http://www.ijo.in/article.asp?issn=0301-4738;year=2014;volume=62;issue=2;spage=219;epage=223;aulast=Jonas;type=0