Indian Journal of Ophthalmology

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 62  |  Issue : 3  |  Page : 295--298

Intraocular soluble intracellular adhesion molecule-1 correlates with subretinal fluid height of diabetic macular edema


Dan Zhu, He Zhu, Chunyan Wang, Dayong Yang 
 Department of Ophthalmology, the Affiliated Hospital of Inner Mongolia Medical College, Hohhot, Inner Mongolia, China

Correspondence Address:
Dan Zhu
the Affiliated Hospital of Inner Mongolia Medical College, No.1 Tongdaobei Street, 010050, Hohhot, Inner Mongolia
China

Objective: To investigate the correlations between aqueous concentrations of vascular endothelial growth factor (VEGF), monocyte chemoattractant protein-1 (MCP-1), soluble intracellular adhesion molecule-1 (sICAM-1) and diabetic macular edema (DME). Materials and Methods: VEGF, MCP-1 and sICAM-1 concentrations in aqueous humor samples of 22 patients with DME and 23 patients with cataract of a control group were measured with solid-phase chemiluminescence immunoassay. Results: Aqueous VEGF (89.2 ± 58.5 pg/ml versus 48.5 ± 27.8 pg/ml, P = 0.006), MCP-1 (684.2 ± 423.4 pg/ml versus 432.4 ± 230.4 pg/ml, P = 0.019) and sICAM-1 (3213.8 ± 2581.6 pg/ml versus 260.2 ± 212.2 pg/ml, P < 0.001) all vary significantly between DME group and control group. Maximum height of submacular fluid measured by Optical coherence tomography (OCT) was significantly associated with aqueous sICAM-1 (r = -0.45, P = 0.034). The maximum height of macular thickness measured by OCT was not significantly associated with either VEGF (P = 0.300), MCP-1 (P = 0.320) or sICAM-1 (P = 0.285). Conclusions: Our results suggest that sICAM-1 may majorly contribute to the formation of subretinal fluid in DME patients and imply that MCP-1 and sICAM-1 may be the potential therapy targets, besides VEGF.


How to cite this article:
Zhu D, Zhu H, Wang C, Yang D. Intraocular soluble intracellular adhesion molecule-1 correlates with subretinal fluid height of diabetic macular edema.Indian J Ophthalmol 2014;62:295-298


How to cite this URL:
Zhu D, Zhu H, Wang C, Yang D. Intraocular soluble intracellular adhesion molecule-1 correlates with subretinal fluid height of diabetic macular edema. Indian J Ophthalmol [serial online] 2014 [cited 2020 Jul 2 ];62:295-298
Available from: http://www.ijo.in/article.asp?issn=0301-4738;year=2014;volume=62;issue=3;spage=295;epage=298;aulast=Zhu;type=0