Indian Journal of Ophthalmology

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 62  |  Issue : 9  |  Page : 917--922

Relationship between systemic hypertension, perfusion pressure and glaucoma: A comparative study in an adult Indian population


Amit K Deb1, Subashini Kaliaperumal1, Vasudev A Rao1, Sabyasachi Sengupta2 
1 Department of Ophthalmology, Jawaharlal Institute of Post Graduate Medical Education and Research, Gorimedu, India
2 Vitreoretina Services, Aravind Eye Hospital, Thavalakuppam, Pondicherry, India

Correspondence Address:
Amit K Deb
Plot No. 44, Raja Annamalai Nagar, Gorimedu Post, Puducherry - 605 006
India

Aims: To study the relationship between blood pressure (BP), intraocular pressure (IOP), mean ocular perfusion pressure (MOPP) and primary open angle glaucoma (POAG) in patients with hypertension and compare it to a control group of normotensives. Design: Cross-sectional observational study. Materials and Methods: A total of 108 subjects with primary hypertension and 100 age-matched controls without hypertension were enrolled for the study. IOP measurement using Noncontact Tonometer and dilated fundus evaluation using + 90 D lens were done for all cases. Single recording of BP was taken. Gonioscopy, Humphrey�SQ�s central visual fields, optical coherence tomography and pachymetry were done for all subjects with IOP > 21 mm Hg or C: D ratio ≥ 0.5 or asymmetry of > 0.2. Statistical Analysis: Univariate and multivariate multinomial regression models were used to determine the association between covariates and risk of glaucoma or glaucoma suspect. Results: There was no difference in the glaucoma status between subjects with and without hypertension. Subjects on antihypertensive medications were 1΍ times more likely to have suspicious glaucoma (odds ratio [OR] =1.56] and nearly twice as likely to have POAG (OR = 1.85). In addition, we found a 31% and 12% reduction in risk of having POAG (95% confidence interval [CI] =13-45%, P = 0.001) and glaucoma suspect (95% CI = 2-21%, P = 0.03) respectively with every 1 mm Hg increment in MOPP. Conclusion: Subjects on antihypertensive medications are more likely to have either glaucoma or glaucoma suspect, and higher ocular perfusion pressure offers relative protection from glaucomatous damage.


How to cite this article:
Deb AK, Kaliaperumal S, Rao VA, Sengupta S. Relationship between systemic hypertension, perfusion pressure and glaucoma: A comparative study in an adult Indian population .Indian J Ophthalmol 2014;62:917-922


How to cite this URL:
Deb AK, Kaliaperumal S, Rao VA, Sengupta S. Relationship between systemic hypertension, perfusion pressure and glaucoma: A comparative study in an adult Indian population . Indian J Ophthalmol [serial online] 2014 [cited 2024 Mar 29 ];62:917-922
Available from: https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=2014;volume=62;issue=9;spage=917;epage=922;aulast=Deb;type=0