Indian Journal of Ophthalmology

PHOTO ESSAY
Year
: 2015  |  Volume : 63  |  Issue : 2  |  Page : 162--163

Angiographic and spectral domain optical coherence tomography features in case of Vogt-Koyanagi-Harada disease


Manish P Nagpal, Kalyani J Bhatt, Navneet S Mehrotra, Sangeeta D Goswami 
 Department of Retina and Vitreous, Retina Foundation, Rajbhavan Road, Ahmedabad, Gujarat, India

Correspondence Address:
Dr. Manish P Nagpal
Retina Foundation, Asopalav Eye Hospital, Rajbhavan Road, Underbridge, Shahibaug, Ahmedabad - 380 004, Gujarat
India




How to cite this article:
Nagpal MP, Bhatt KJ, Mehrotra NS, Goswami SD. Angiographic and spectral domain optical coherence tomography features in case of Vogt-Koyanagi-Harada disease.Indian J Ophthalmol 2015;63:162-163


How to cite this URL:
Nagpal MP, Bhatt KJ, Mehrotra NS, Goswami SD. Angiographic and spectral domain optical coherence tomography features in case of Vogt-Koyanagi-Harada disease. Indian J Ophthalmol [serial online] 2015 [cited 2024 Mar 28 ];63:162-163
Available from: https://journals.lww.com/ijo/pages/default.aspx/text.asp?2015/63/2/162/154403


Full Text

A 13-year-old male patient came with diminution of vision in right eye for last 10 days. His best-corrected visual acuity (BCVA) was 20/120 OD and 20/30 OS. Anterior segment OU was normal. Dilated fundus OU showed multiple serous retinal detachments, elevation of the peripapillary retinochoroidal layer and hyperemia of optic nerve head [Figure 1]. Spectral domain optical coherence tomography (SD-OCT) and combined fluorescein-indocyanine green angiography (FA-ICGA) confirmed the diagnosis of Vogt-Koyanagi-Harada (VKH). SD-OCT showed multilobular serous retinal detachment, subretinal septas, and hyperreflective dot reflexes in subretinal fluid [Figure 2]. Early-phase FA showed multiple points of dye leakage at the level of the retinal pigment epithelium (RPE), and late-phase FA showed pooling of dye [Figure 3]. ICGA revealed multiple hypofluorescent dark spots during the early and late phase [Figure 3]. Following the course of intravenous pulse therapy and oral steroids, BCVA improved to 20/20 OU with resolution on OCT after 1-month [Figure 4].{Figure 1}{Figure 2}{Figure 3}{Figure 4}

 Discussion



Vogt-Koyanagi-Harada disease is a bilateral granulomatous panuveitis associated with autoimmunity against the melanocytes accompanied by neurologic, auditory, and/or integumentary symptoms and signs. The acute uveitic stage of VKH is characterized by bilateral anterior and/or posterior segment involvement with exudative retinal detachment. [1]

In acute stage VKH, specific fundus fluorescein angiography findings include choriocapillaris filling delay, multiple pinpoint leakage at the level of RPE, choroidal folds, and pooling of dye in areas of serous detachment in the late phase. [2]

Indocyanine green angiography shows early choroidal stromal vessel hyperfluorescence and leakage, fuzzy choroidal stromal vessels in the intermediate phase, and the presence of hypofluorescent dark spots. [3]

Optical coherence tomography reveals multilobular serous retinal detachment and subretinal septas that divide the subretinal space into several compartments which contain numerous hyper-reflective dot reflexes. [4] These represent inflammatory products like fibrin. Undulations and bumps on the RPE surface have also been described. [5] There is complete resolution of the serous retinal detachments and subretinal septas after steroid pulse therapy.

References

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