BRIEF COMMUNICATION
Year : 2016 | Volume
: 64 | Issue : 2 | Page : 153--157
Multi-drug resistant Pseudomonas aeruginosa keratitis and its effective treatment with topical colistimethate
Samrat Chatterjee, Deepshikha Agrawal Cornea and Anterior Segment Services, MGM Eye Institute, Raipur, Chhattisgarh, India
Correspondence Address:
Dr. Samrat Chatterjee MGM Eye Institute, 5th Mile, Vidhan Sabha Road, Raipur - 492 007, Chhattisgarh India
The purpose was to evaluate the clinical outcome in multi-drug resistant Pseudomonas aeruginosa (MDR-PA) bacterial keratitis and report the successful use of an alternative antibiotic, topical colistimethate in some of them. The medical records of 12 culture-proven MDR-PA keratitis patients, all exhibiting in vitro resistance by Kirby–Bauer disc diffusion method to ≥ three classes of routinely used topical antibiotics were reviewed. Eight patients were treated with 0.3% ciprofloxacin or ofloxacin, 1 patient with 5% imipenem/cilastatin and 3 patients with 1.6% colistimethate. The outcomes in 8 eyes treated with only fluoroquinolones were evisceration in 4 eyes, therapeutic corneal graft in 1 eye, phthisis bulbi in 1 eye, and no improvement in 2 eyes. The eye treated with imipenem/cilastin required a therapeutic corneal graft. All the three eyes treated with 1.6% colistimethate healed. Colistimethate may prove to be an effective alternative antibiotic in the treatment of MDR-PA keratitis.
How to cite this article:
Chatterjee S, Agrawal D. Multi-drug resistant Pseudomonas aeruginosa keratitis and its effective treatment with topical colistimethate.Indian J Ophthalmol 2016;64:153-157
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How to cite this URL:
Chatterjee S, Agrawal D. Multi-drug resistant Pseudomonas aeruginosa keratitis and its effective treatment with topical colistimethate. Indian J Ophthalmol [serial online] 2016 [cited 2024 Mar 28 ];64:153-157
Available from: https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=2016;volume=64;issue=2;spage=153;epage=157;aulast=Chatterjee;type=0 |
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