Indian Journal of Ophthalmology

LETTER TO THE EDITOR
Year
: 2016  |  Volume : 64  |  Issue : 2  |  Page : 171--172

Handheld spectral domain optical coherence tomography seems to be a must-have device for future treatment methods of hereditary maculopathies


Oktay Diner1, Yakup Aksoy2, Abdullah Kaya3, Mehmet Koray SevinÁ4,  
1 Department of Ophthalmology, Erzurum Military Hospital, Erzurum, Turkey
2 Department of Ophthalmology, Girne Military Hospital, Girne, Cyprus
3 Department of Ophthalmology, Anıttepe Military Dispensary, Ankara, Turkey
4 Department of Ophthalmology, Beytepe Military Hospital, Ankara, Turkey

Correspondence Address:
Dr. Abdullah Kaya
Department of Ophthalmology, Anıttepe Military Dispansery, Ankara
Turkey




How to cite this article:
Diner O, Aksoy Y, Kaya A, SevinÁ MK. Handheld spectral domain optical coherence tomography seems to be a must-have device for future treatment methods of hereditary maculopathies.Indian J Ophthalmol 2016;64:171-172


How to cite this URL:
Diner O, Aksoy Y, Kaya A, SevinÁ MK. Handheld spectral domain optical coherence tomography seems to be a must-have device for future treatment methods of hereditary maculopathies. Indian J Ophthalmol [serial online] 2016 [cited 2020 Jul 10 ];64:171-172
Available from: http://www.ijo.in/text.asp?2016/64/2/171/179730


Full Text

Dear Sir,

We have read with great interest the article entitled “The use of handheld spectral domain optical coherence tomography in pediatric ophthalmology practice: Our experience of 975 infants and children.”[1] We thank the author for presenting their experiences with handheld spectral domain optic coherence tomography (SD-OCT). This study has showed us that SD-OCT is a revolutionary investigation for diagnosis in pediatric population. Especially, early detection of maculopathies by this device is very exciting. Hereditary maculopathies often do not give any clinical finding in the examination of children. If there could be a development in treatment of these diseases, it will be crucial to detect maculopathy early to prevent permanent photoreceptor and/or retina pigment epithelium (RPE) injuries. Hereditary maculopathies are generally genetic disorders and characterized by progressive photoreceptor and/or RPE degeneration.[2] There are promising studies about the treatment of these diseases by gene therapy. In a recent study, retinitis pigmentosa GTPase regulator gene augmentation by adeno-associated virus 2/5 vector has been shown to prevent photoreceptor degeneration.[3] However, it investigated that this therapy could only be useful when applied before degeneration of photoreceptors. Hence, if it could be possible to cure maculopathies by genetic methods, early diagnose will be very important to survive photoreceptors. Another treatment area for hereditary maculopathies is cell replacement therapy. It could be possible to transplant stem-cell-derived photoreceptor precursors to the diseased eye. There is increasing publication about this therapy.[4] If there will be possible to apply such a therapy, early diagnose, and treatment of disease will provide better outcomes and prevent amblyopia. Thus, handheld SD-OCT seems to be a must-have device for future revolutionary treatment methods in this area of ophthalmology.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

References

1Mallipatna A, Vinekar A, Jayadev C, Dabir S, Sivakumar M, Krishnan N, et al. The use of handheld spectral domain optical coherence tomography in pediatric ophthalmology practice: Our experience of 975 infants and children. Indian J Ophthalmol 2015;63:586-93.
2Megaw RD, Soares DC, Wright AF. RPGR: Its role in photoreceptor physiology, human disease, and future therapies. Exp Eye Res 2015;138:32-41.
3Beltran WA, Cideciyan AV, Lewin AS, Iwabe S, Khanna H, Sumaroka A, et al. Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa. Proc Natl Acad Sci U S A 2012;109:2132-7.
4MacLaren RE, Pearson RA, MacNeil A, Douglas RH, Salt TE, Akimoto M, et al. Retinal repair by transplantation of photoreceptor precursors. Nature 2006;444:203-7.