Indian Journal of Ophthalmology

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 64  |  Issue : 5  |  Page : 358--363

Lamina depth and thickness correlate with glaucoma severity


Martha Kim, Karine D Bojikian, Mark A Slabaugh, Leona Ding, Philip P Chen 
 Department of Ophthalmology, Dongguk University Ilsan Hospital, Goyang, Korea; Department of Ophthalmology, University of Washington, Seattle, WA, USA

Correspondence Address:
Prof. Martha Kim
Department of Ophthalmology, Dongguk University Ilsan Hospital, 27, Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 410-773, Korea

Purpose: To evaluate the correlation between lamina cribrosa (LC) morphology and glaucoma severity in patients with primary forms of open-angle glaucoma (OAG) using enhanced depth imaging spectral-domain optical coherence tomography (SD-OCT) and Humphrey visual field test (HVF). Subjects and Methods: Patients with OAG (n = 166), divided into normal-tension glaucoma (NTG) and high-tension glaucoma (HTG) groups (n = 66 and n = 100), were imaged using SD-OCT to obtain horizontal B-scan images of the optic nerve head (ONH). Laminar depth (LD) and laminar thickness (LT) were measured at the center of ONH. Results: The mean (±standard deviation) values of LD, LT, and visual field mean deviation (MD) were 555.4 ± 142.3 μm, 179.9 ± 49.7 μm, and − 5.7 ± 6.4 dB, respectively. In the multivariate linear regression analysis, LD, LT, and intraocular pressure (IOP) were significantly correlated with MD (P = 0.007, P = 0.037, and P = 0.004, respectively). In the subgroup analyses, only LD was associated with MD in the NTG group (n = 66), whereas LT and IOP were correlated with MD in the HTG group (n = 100). Neither axial length nor central corneal thickness was associated with LD or LT. Conclusions: Glaucoma severity, as measured by HVF MD, shows significant correlations with LD and LT, with greater severity associated with increasing LD and decreasing LT. Normal- and high-tension OAG patients have different associations with LD and LT, which implies that the pathogenesis of these two entities might be different.


How to cite this article:
Kim M, Bojikian KD, Slabaugh MA, Ding L, Chen PP. Lamina depth and thickness correlate with glaucoma severity.Indian J Ophthalmol 2016;64:358-363


How to cite this URL:
Kim M, Bojikian KD, Slabaugh MA, Ding L, Chen PP. Lamina depth and thickness correlate with glaucoma severity. Indian J Ophthalmol [serial online] 2016 [cited 2020 Jul 4 ];64:358-363
Available from: http://www.ijo.in/article.asp?issn=0301-4738;year=2016;volume=64;issue=5;spage=358;epage=363;aulast=Kim;type=0