Indian Journal of Ophthalmology

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 65  |  Issue : 11  |  Page : 1109--1113

Immunohistochemical expression of X-linked inhibitor of apoptosis in eyelid sebaceous gland carcinoma predicts a worse prognosis


Perumal Jayaraj1, Seema Sen2, PS Dhanaraj1, Romika Jhajhria3, Shalu Singh4, Vijay Kumar Singh2 
1 Department of Zoology, Sri Venkateswara College, University of Delhi (South Campus), New Delhi, India
2 Department of Ocular Pathology, Dr. R. P. Centre, AIIMS, New Delhi, India
3 Department of Biotechnology, Amity University, Gurgaon, Haryana, India
4 Department of Biochemistry, Jamia Millia Islamia, New Delhi, India

Correspondence Address:
Perumal Jayaraj
Department of Zoology, Sri Venkateswara College, University of Delhi (South Campus), Dhaula Kuan, New Delhi - 110 021
India

Purpose: Overexpression of the inhibitors of apoptosis proteins have been demonstrated in a variety and of solid tumors including melanomas and nonmelanomas skin cancers. X-linked inhibitor of apoptosis protein (XIAP) is an inhibitor of apoptosis which prevents apoptosis by inhibiting caspases 9, 7, and 3. The prognostic value of XIAP in sebaceous gland carcinoma (SGC) remains unexplored. Methods: The immunohistochemical expression of XIAP was evaluated in 29 SGC cases. Results: The cytoplasmic overexpression of XIAP was detected in 62% SGC cases. XIAP expression was found to be significantly associated with advanced age, large tumor size, and with reduced disease-free survival (P = 0.0174). XIAP expression and advance tumor Grade III emerged as significant risk factors on univariate analysis. On stepwise multivariate analysis, both increased cytoplasmic XIAP expression and high tumor grade were found to be significantly associated with recurrence. Patients with low XIAP immunoexpression had a longer disease-specific survival than those with high expression in the 5-year follow-up. Conclusion: The present study demonstrates at the immunohistochemical level that XIAP is overexpressed in SGC and that high expression could be of biological significance in the development of eyelid SGC. Our finding suggests that up-regulation of XIAP may aggravate tumor metastasis in SGC.


How to cite this article:
Jayaraj P, Sen S, Dhanaraj P S, Jhajhria R, Singh S, Singh VK. Immunohistochemical expression of X-linked inhibitor of apoptosis in eyelid sebaceous gland carcinoma predicts a worse prognosis.Indian J Ophthalmol 2017;65:1109-1113


How to cite this URL:
Jayaraj P, Sen S, Dhanaraj P S, Jhajhria R, Singh S, Singh VK. Immunohistochemical expression of X-linked inhibitor of apoptosis in eyelid sebaceous gland carcinoma predicts a worse prognosis. Indian J Ophthalmol [serial online] 2017 [cited 2019 Nov 11 ];65:1109-1113
Available from: http://www.ijo.in/article.asp?issn=0301-4738;year=2017;volume=65;issue=11;spage=1109;epage=1113;aulast=Jayaraj;type=0