Indian Journal of Ophthalmology

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 66  |  Issue : 1  |  Page : 55--60

Topical chemotherapy for giant ocular surface squamous neoplasia of the conjunctiva and cornea: Is surgery necessary?


Sonal S Chaugule, Jennifer Park, Paul T Finger 
 Department of Ocular Tumor and Orbital Disease, The New York Eye Cancer Center; Department of Ophthalmology, The New York Eye and Ear Infirmary of Mt. Sinai, New York, NY, USA

Correspondence Address:
Dr. Paul T Finger
The New York Eye Cancer Center, Suite 5B, 5th Floor, 115 East 61st Street, New York, NY
USA

Purpose: The purpose of this study is to report on the efficacy and safety of topical chemotherapy alone for giant ocular surface squamous neoplasia (OSSN). Methods: In this retrospective, interventional series, 10 eyes with giant OSSN underwent exfoliative biopsy to confirm the diagnosis followed by application of interferon alpha 2b (IFN α2b) and/or 5 fluorouracil, 1% (5FU). Reported outcome measures were tumor response, visual acuity, recurrence, systemic metastasis, and treatment complications. Results: Ten patients (3 female, 7 male) had a mean age of 73 (median, 69; range 40–89) years. Mean tumor diameter was 13.1 (median, 12.3; range 8.2–19.4) mm. Five (50%) eyes were treated with IFN-α2b alone; 1 (10%) with 5-FU alone and 4 (40%) required both IFN-α2b and 5-FU. The mean duration of treatment was 3, 0.5, and 6.4 months for IFN-α2b alone, 5-FU alone, and both IFN-α2b and 5-FU respectively. Complete tumor response was observed in all 10 cases at mean follow-up of 12.8 (median, 11.5; range, 3–25) months. Complications noted were transient irritation and burning (n = 4), dry eyes (n = 2), and transient flu-like symptoms (n = 2). There was no evidence of chemotherapy-related symblepharon, stem cell deficiency, scleral thinning, or corneal opacity. There were no tumor recurrences, and no patient required surgical excision or cryotherapy. Conclusion: Topical chemotherapy was a safe and effective treatment, inducing complete regression in all cases of giant OSSN in this series. There were no sight-limiting complications.


How to cite this article:
Chaugule SS, Park J, Finger PT. Topical chemotherapy for giant ocular surface squamous neoplasia of the conjunctiva and cornea: Is surgery necessary?.Indian J Ophthalmol 2018;66:55-60


How to cite this URL:
Chaugule SS, Park J, Finger PT. Topical chemotherapy for giant ocular surface squamous neoplasia of the conjunctiva and cornea: Is surgery necessary?. Indian J Ophthalmol [serial online] 2018 [cited 2019 Sep 19 ];66:55-60
Available from: http://www.ijo.in/article.asp?issn=0301-4738;year=2018;volume=66;issue=1;spage=55;epage=60;aulast=Chaugule;type=0