Indian Journal of Ophthalmology

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 66  |  Issue : 1  |  Page : 83--88

Retinal pigment epithelium aperture: A late-onset complication in adult-onset foveomacular vitelliform dystrophy


Reema Bansal, Sonam Yangzes, Ramandeep Singh, Deeksha Katoch, Mangat R Dogra, Vishali Gupta, Amod Gupta 
 Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
Dr. Amod Gupta
Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh
India

Abstract

Purpose: The purpose of the study was to report aperture of retinal pigment epithelium (RPE) as a late complication and an unreported finding during the natural course of adult-onset foveomacular vitelliform dystrophy (AFVD). Methods: Four diagnosed cases of AFVD followed for a period ranging from 4 to 8 years. All patients had documented records of clinical examination, fundus autofluorescence and fluorescein angiography, and spectral domain-optical coherence tomography at regular intervals. Results: Besides the known stages in the natural course of AFVD, RPE aperture was noted as an additional finding during the vitelliruptive stage of the disease. The vitelliform material was noted beneath the disrupted RPE before disappearance. Accumulation of vitelliform material continued even after the vitelliruptive stage. Conclusion: RPE aperture may represent an ongoing process in the natural course of AFVD.



How to cite this article:
Bansal R, Yangzes S, Singh R, Katoch D, Dogra MR, Gupta V, Gupta A. Retinal pigment epithelium aperture: A late-onset complication in adult-onset foveomacular vitelliform dystrophy.Indian J Ophthalmol 2018;66:83-88


How to cite this URL:
Bansal R, Yangzes S, Singh R, Katoch D, Dogra MR, Gupta V, Gupta A. Retinal pigment epithelium aperture: A late-onset complication in adult-onset foveomacular vitelliform dystrophy. Indian J Ophthalmol [serial online] 2018 [cited 2024 Mar 28 ];66:83-88
Available from: https://journals.lww.com/ijo/pages/default.aspx/text.asp?2018/66/1/83/221812


Full Text



Adult-onset foveomacular vitelliform dystrophy (AFVD) is characterized by bilateral subretinal yellowish macular lesions usually seen between fourth and fifth decades of life.[1],[2] Although the long-term follow-up of AFVD reveals progressive stages (vitelliform, pseudohypopyon, vitelliruptive, and atrophic) during its natural course, the exact underlying mechanism into its pathogenesis is not well understood.[3] It is still not known how the vitelliform material gets reabsorbed.[3]

The imaging modalities such as fundus autofluorescence (FAF) and spectral domain-optical coherence tomography (SD-OCT) show characteristic findings as the lesions evolve through various stages.[2],[3],[4],[5] We observed aperture of retinal pigment epithelium (RPE) as a new finding on SD-OCT during the natural course of AFVD that has not been reported so far.

 Methods



We performed a retrospective analysis of a case series of four patients (age range: 45–82 years) with AFVD who presented in the retina services between 2000 and 2008. Institute Ethics Committee approval was obtained. The study adhered to the tenets of the Declaration of Helsinki. The inclusion criteria were the presence of AFVD and absence of dry age-related macular degeneration (AMD)/choroidal neovascular membrane (CNVM) by clinical records and multimodal image analysis, minimum 1-year follow up, and complete documented records of ophthalmic examination including best-corrected visual acuity (BCVA), slit-lamp biomicroscopic examination, fundus photography, fundus fluorescein angiography (FFA), FAF imaging, and SD-OCT (Cirrus HD-OCT [Carl Zeiss Meditec, Dublin, CA, USA] or Spectralis HRA + OCT [Heidelberg Engineering, Heidelberg, Germany]) done at baseline and follow-up visits. Eyes with additional retinal pathologies (such as diabetic retinopathy, vascular occlusion, macular hole, and other vitreoretinal interface disorders) were excluded from the study.

Case examples

Case example 1

A 45-year-old female presented with complaints of metamorphopsia. Her BCVA was 20/20 in the right eye and 20/40 in the left eye. Fundus examination revealed subfoveal yellowish deposit in the right eye and foveal scar in the left eye [Figure 1]. The right eye FFA showed a central hypofluorescence with a halo of hyperfluorescence and the left eye showed a central small area of hyperfluorescence with surrounding hypofluorescence [Figure 1]. On FAF, the right eye lesion was brightly hyperautofluorescent in the center, surrounded by a border of hypoautofluorescence. The SD-OCT showed a hyperreflective complex in the outer retinal layers that extended into the Henle's layer with aperture of the ellipsoid zone and the outer limiting membrane [Figure 2]a. The RPE could not be differentiated from this complex. She received two monthly injections of bevacizumab in the left eye for an erroneous diagnosis of occult CNVM. Two years later, the patient complained of increased metamorphopsia in the right eye. There was a disappearance of the yellowish deposits in the right eye with atrophic changes in the fovea, and on FAF, the lesion now appeared hypoautofluorescent. The SD-OCT scan showed disappearance of the previously accumulated hyperreflective material, baring of the Bruch's membrane, and discontinuity of photoreceptor (PR)-RPE complex [Figure 2]b. Three years later, the right eye fundoscopy showed the reappearance of the yellowish material (adjacent to the previous atrophic lesion), which was hyperautofluorescent and corresponded to new hyperreflective deposits beneath the ellipsoid zone, at the border of previously identified region of missing PR-RPE complex [Figure 2]c. The left eye too underwent similar changes with the RPE aperture noted 5 years after presentation [Figure 2]d. The BCVA was 20/40 in both eyes at 5-year follow-up.{Figure 1}{Figure 2}

Case example 2

A 70-year-old male with metamorphopsia (diagnosed as occult CNVM elsewhere) presented with BCVA of 20/30 in both eyes. The right eye had a hypopigmented, yellowish subfoveal lesion that was hyperautofluorescent on FAF, suggestive of AFVD [Figure 3]. The SD-OCT line scan passing through the lesion showed a pigment epithelium detachment (PED) with hyperreflective material in the outer retinal layers (anterior to PED) that was still persisting 2 years later [Figure 4]a and developed a small RPE aperture 6 months later [Figure 4]b. Three years further on, the yellow material disappeared and the lesion became hypoautofluorescent on FAF corresponding to RPE aperture. The PED had collapsed with baring of the Bruch's membrane [Figure 4]c. Still, 3 years later, the yellowish material, brightly hyperautofluorescent reaccumulated next to the region of RPE aperture and corresponded to the newly appeared hyperreflective material under the ellipsoid zone [Figure 4]d. The BCVA in the right eye was 20/80. The left eye too had a similar course.{Figure 3}{Figure 4}

Case example 3

A 68-year-old male presented with metamorphopsia and BCVA of 20/30 in the right eye and 20/100 in the left eye. The left eye yellowish subfoveal lesion was hyperfluorescent on FFA and corresponded to the RPE aperture on SD-OCT with hyporeflectivity anterior, as well as posterior, to RPE aperture, suggesting a completely reabsorbed vitelliform material [Figure 5]a. Three years later, the RPE aperture and PED increased, with appearance of new hyperreflective material under the disrupted RPE [Figure 5]b. Over the next 2 years, fundus examination and SD-OCT showed complete disappearance of the yellowish material both above and below RPE [Figure 5]c. Two years later, whereas the SD-OCT findings remained the same through the center of the hypoautofluorescent atrophic lesion [Figure 5]d, a new hyperautofluorescent halo appeared around this lesion, with a corresponding hyperreflective material both above and below the RPE [Figure 6]. The BCVA at last follow-up was 20/30 in the right eye and 20/100 in the left eye.{Figure 5}{Figure 6}

Case example 4

A 82-year-old male with metamorphopsia had BCVA 20/30 in the right eye and 20/100 in the left eye. An ill-defined staining of subfoveal lesion on FA led to a diagnosis of occult CNVM in the left eye, for which he received two intravitreal bevacizumab injections. The FAF imaging showed a mixed pattern of the FAF [Figure 7]a. Two years later, the lesion showed an increasing hypoautofluorescence [Figure 7]b. The SD-OCT scan revealed three different stages of the disease as the lesion showed varying levels of AF, i.e., vitelliform stage through the hyperautofluorescent part of the lesion [Figure 8]a, vitelliruptive stage through the junction of hyper- and hypoautofluorescent parts [Figure 8]b, and RPE aperture through the completely hypoautofluorescent part of the lesion [Figure 8]c.{Figure 7}{Figure 8}

 Discussion



An RPE aperture has been recently described as a new finding, previously unreported, in the evolution of avascular PED.[6] We observed this finding in four of our patients of AFVD during a long-term follow up, two of which had a coexisting avascular PED. The multimodal imaging analysis revealed that this aperture in the RPE corresponded to the clinical disappearance of the yellow vitelliform material and conversion of the lesions showing hyperautofluorescence to hypoautofluorescence on the FAF. This finding is consistent with that described by Querques et al. where the lesion representing drusenoid material revealed focal hyperautofluorescence preceding the development of RPE aperture and turned hypoautofluorescent with its atrophic progression.[6] Besides showing the RPE aperture, the SD-OCT in our patients also revealed the disappearance of the hyperreflective vitelliform deposits till it appeared again years later. The yellowish appearing vitelliform material in AFVD represents the PR outer segments debris and lipofuscin accumulated between the neurosensory retina and the RPE.[2],[4] While the FFA findings may often be inconclusive to differentiate AFVD from other conditions mimicking it, multimodal imaging including FAF and SD-OCT are extremely valuable in confirming its diagnosis, staging the disease, and studying its natural course.[5] Pierro et al. described a common finding of a well-defined subretinal thickening of the RPE on SD-OCT in all of 72 eyes they studied, with varying features of FFA and indocyanine green angiography.[7] They believed that metamorphopsia in these patients resulted from compression of the neurosensory retina overlying the subretinal vitelliform deposit, and visual loss occurred due to thinning of the neurosensory retina.[7] The OCT helps in preventing misdiagnosing AFVD as CNVM by showing a subretinal lesion with medium-high reflectivity with a neurosensory wedge-shaped elevation.[8]

While the PR layer gets elevated and separated from RPE, various OCT-based studies have shown RPE layer to be linear and not elevated.[4],[9] Puche et al. described different morphological features in eyes with AFVD using high-resolution SD-OCT.[10] The subretinal vitelliform material was mostly heterogeneous, highly reflective, and dome shaped. Some eyes showed hyperreflective clumps within the outer plexiform and outer nuclear layers. The PR inner segment/outer segment (IS/OS) interface, now labeled as the ellipsoid zone showed high reflectivity, and appeared irregular and discontinuous in few eyes. While some eyes showed discrete RPE detachments, few showed RPE irregularities with hyperreflective mottling on its inner aspect. The subretinal accumulation of vitelliform material was followed by alterations in PR IS/OS interface, pigment migration toward inner retinal layers, and fluid accumulation. Changes in the RPE included atrophy/hypertrophy or rarely sub-RPE deposits. Chen et al. have described intraretinal hyperreflective foci in patients with the acquired vitelliform lesions, which represent cells of the same origin as those found in vitelliform lesions.[11] Aperture of the ellipsoid zone facilitates inward migration of the vitelliform material, followed by its lateral dissipation within the inner retinal layers. None have reported RPE aperture as seen in our study.

As described by Querques et al.,[6] our series has the common findings of the absence of any rippling or retraction at the edges of the RPE aperture (differentiating it from RPE rip or tear) and hypoautofluorescence on FAF corresponding to the aperture on SD-OCT. However, the subretinal fluid is present in only two of our eyes with coexisting PED, which differentiates it from the previous series that had subretinal fluid in all eyes. Furthermore, though we did not quantitatively assess the size of the RPE aperture, it did not show any apparent increase in size over a follow-up of as long as 2 years as seen in case example 3 [Figure 5]b and [Figure 5]c.

Sub-RPE changes in AFVD have been rarely mentioned in clinical or clinicopathologic studies.[10],[12],[13],[14] Our short case series demonstrated a sub-RPE hyperreflective lesion following development of RPE aperture indicating a sub-RPE migration of the vitelliform material and absorption from thereof. Previously, a well-circumscribed elevation of RPE has been reported by Saito et al., with an underlying lesion beneath with a moderate-high reflectivity.[15] Clinicopathologic studies on AFVD have revealed atrophy of PRs and RPE,[12],[13],[14] collection of eosinophilic material,[12] pigmented cells containing periodic acid–Schiff (PAS)-positive material and pigmented cells containing lipofuscin in the subretinal space.[13],[15] Dense eosinophilic material and PAS-positive material have also been shown in the space between Bruch's membrane and RPE.[12],[13] Based on our observations in these four patients, we suggest that this migration of the vitelliform material may have been facilitated by an aperture in the RPE.

As AFVD progresses, a change in the composition of the vitelliform lesions changes the clinical and morphological appearance of these lesions. The acquired vitelliform material that collects as a result of impaired phagocytosis of shed PR outer segments due to dysfunctional RPE is believed to show a gradual spontaneous resolution due to the ongoing PR loss.[2] While the RPE tears associated with PED/wet AMD occur secondary to hydrostatic forces by the sub-RPE fluid/membrane,[16],[17] it may be likely that this phenomenon in AFVD may represent the loss of integrity of RPE cells that have undergone atrophy following a chronic detachment. It is difficult to say whether the regression of vitelliform material leads to progressive atrophy of the RPE as hypothesized in context to drusenoid PEDs,[6] or the aperture of the RPE is an additional mechanism for the disappearance of the vitelliform material. Histological demonstration of intraretinal RPE cells and vitelliform lesions in a large drusenoid PED [18] and the coexistence of serous PEDs in two of our patients with AFVD may suggest a common underlying mechanism in the pathogenesis of RPE aperture.

Our series has a few limitations of being a retrospective study. The follow-up scans obtained by the SD-OCT (Cirrus HD-OCT [Carl Zeiss Meditec, Dublin, CA, USA) lack the exact registration of the lesions. Two of our patients showed PED, a finding more consistent with AMD than AFVD. However, these patients lacked the typical findings of AMD. Nevertheless, AMD has been reported as one of the non-AFVD entities associated with acquired vitelliform lesions.[2] A small number of eyes, variable follow-up, lack of quantitative assessment of the RPE aperture, and lack of histologic correlation are other drawbacks of our study.

 Conclusion



Complications such as CNVM, macular hole, and retinal detachment have been occasionally reported in AFVD. Our study suggests RPE aperture as another possible complication in these eyes. We also demonstrate for the first time that there is progressive accumulation of the vitelliform material even after the lesions have reached the vitelliruptive and atrophic stage in the natural course of the AFVD. We believe that the RPE aperture beginning simultaneous or subsequent to the onset of vitelliruptive stage may occur during the natural course of AFVD.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

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