Indian Journal of Ophthalmology

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 67  |  Issue : 8  |  Page : 1297--1302

Effect of topical glaucoma medication on tear lipid layer thickness in patients with unilateral glaucoma


Sang M Lee1, Ji-Eun Lee2, Sung I Kim1, Jae H Jung3, Jonghoon Shin2 
1 Department of Ophthalmology, College of Medicine, Pusan National University Yangsan Hospital, Yangsan, South Korea
2 Department of Ophthalmology, College of Medicine; Department of Ophthalmology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Korea
3 Department of Ophthalmology, College of Medicine, Seoul National University Hospital, Seoul, South Korea

Correspondence Address:
Dr. Jonghoon Shin
Department of Ophthalmology, Pusan National University Yangsan Hospital, 20-Geumo-ro, Mulgeum-eup, Yangsan - 50612
South Korea

Purpose: To compare the lipid layer thickness (LLT) using the LipiView® ocular surface interferometer (TearScience® Inc, Morrisville, NC) between the eye treated with glaucoma medication and untreated normal eye in the unilateral glaucoma patients, and evaluate the effect of topical glaucoma medication on the LLT parameters in glaucoma eyes. Methods: The participants in this cross-sectional comparative study were unilateral glaucoma patients treated with topical glaucoma medications for more than 12 months. Three LLT parameters (average, minimum, and maximum) obtained by the LipiView® were compared between the glaucomatous eye and normal eye. The factors associated with LLT parameters in the eyes treated with glaucoma medication were investigated with multiple regression analysis. Results: Thirty patients with unilateral normal tension glaucoma were enrolled in the present study. Lipid layer average, minimum, and maximum were 64.83 ± 16.50, 51.63 ± 16.73, and 82.53 ± 20.62 in glaucomatous eyes, 77.26 ± 17.81, 62.83 ± 20.99, and 86.13 ± 15.42 in normal eyes. Lipid layer average and minimum were significantly thinner than those in normal eyes (P < 0.001, P < 0.001, respectively). Longer duration of glaucoma eye drops and a greater number of glaucoma medications were associated with the lower LLT average (β = −0.456, P < 0.001, β = −8.517, P = 0.003, respectively), and increasing glaucoma medications have a significant correlation with lower LLT minimum in glaucoma eyes (β = −8.814, P = 0.026). Conclusion: The present study highlights that patients with long-term glaucoma medications need to be assessed for LLT parameters objectively evaluate their ocular surface health.


How to cite this article:
Lee SM, Lee JE, Kim SI, Jung JH, Shin J. Effect of topical glaucoma medication on tear lipid layer thickness in patients with unilateral glaucoma.Indian J Ophthalmol 2019;67:1297-1302


How to cite this URL:
Lee SM, Lee JE, Kim SI, Jung JH, Shin J. Effect of topical glaucoma medication on tear lipid layer thickness in patients with unilateral glaucoma. Indian J Ophthalmol [serial online] 2019 [cited 2024 Mar 19 ];67:1297-1302
Available from: https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=2019;volume=67;issue=8;spage=1297;epage=1302;aulast=Lee;type=0