Indian Journal of Ophthalmology

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 68  |  Issue : 1  |  Page : 35--38

Intrastromal voriconazole: An adjuvant approach for recalcitrant mycotic keratitis


Piyali Konar, Shilpa Joshi, Seema J Mandhare, Rasika Thakur, Madan Deshpande, Ashutosh Dayal 
 Department of Cornea, PBMA's H.V. Desai Eye Hospital, Pune, Maharastra, India

Correspondence Address:
Dr. Piyali Konar
PBMA's H V Desai Eye Hospital, 93/2, Tarvade Vasti, Hadapsar Road, Mohammedwadi, Pune - 411 060, Maharastra
India

Purpose: To evaluate the efficacy of intrastromal voriconazole for the management of fungal keratitis not responding to conventional therapy. Methods: Patients having microbiologically proven fungal keratitis with poor response to 2 weeks of conventional topical therapy were included in the study. After obtaining informed consent, an intrastromal injection of voriconazole was administered around the ulcer. Response to treatment in the form reduction in the size of the ulcer and infiltration was recorded on regular follow-ups. Results: Out of a total of 20 patients, 14 responded to intrastromal treatment and resolved, whereas six patients progressed to perforation. Mean resolution time was 35.5 ± 9.2 days. The most common organism isolated was Fusarium in six patients while Aspergillus and Mucor were isolated in two each. The causative organism could not be isolated in eight patients. The size of the ulcer at presentation and height of hypopyon were found to be significant risk factors associated with treatment outcomes. Conclusion: Intrastromal voriconazole as an adjuvant therapy appeared to be effective in treatment of fungal keratomycosis not responding to conventional therapy, thus, reducing the need for therapeutic or tectonic keratoplasty.


How to cite this article:
Konar P, Joshi S, Mandhare SJ, Thakur R, Deshpande M, Dayal A. Intrastromal voriconazole: An adjuvant approach for recalcitrant mycotic keratitis.Indian J Ophthalmol 2020;68:35-38


How to cite this URL:
Konar P, Joshi S, Mandhare SJ, Thakur R, Deshpande M, Dayal A. Intrastromal voriconazole: An adjuvant approach for recalcitrant mycotic keratitis. Indian J Ophthalmol [serial online] 2020 [cited 2020 Feb 23 ];68:35-38
Available from: http://www.ijo.in/article.asp?issn=0301-4738;year=2020;volume=68;issue=1;spage=35;epage=38;aulast=Konar;type=0