Indian Journal of Ophthalmology

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 68  |  Issue : 8  |  Page : 1556--1562

Ocular surface characterization after allogeneic stem cell transplantation: A prospective study in a referral center


Carmen Alba-Linero1, Marina Rodriguez Calvo de Mora1, Rocío Lavado Valenzuela2, María Jesús Pascual Cascón3, Alejandra Rosario Martín Cerezo3, Martina Álvarez Pérez4, Luis Vicioso Recio6, José Manuel Jerez Aragonés5, José Manuel García Campos6 
1 Ophthalmology Department, Hospital Regional of Malaga, Malaga, Spain
2 Instituto de Investigación Biomédica de Málaga; Laboratorio de Biologia Molecular del Cáncer, Malaga, Spain
3 Department of Hematology, Hospital Regional of Malaga, Malaga, Spain
4 Instituto de Investigación Biomédica de Málaga; Laboratorio de Biologia Molecular del Cáncer; Department of Pathology, School of Medicine, University of Malaga, Malaga, Spain
5 Department of Informatics, School of Engineering, University of Malaga, Malaga, Spain
6 Department of Ophthalmology, Hospital Clínico Universitario of Malaga, Malaga, Spain

Correspondence Address:
Dr. Carmen Alba-Linero
Plaza del Hospital Civil s/n 29009, Malaga, Malaga
Spain

Purpose: To characterize anatomical and functional changes in the ocular surface after hematopoietic stem cell transplantation. Methods: Three groups of patients were included in the study. Group 1: patients who had undergone allogeneic hematopoietic stem cell transplantation (HSCT) (n = 26). Group 2: patients who developed chronic graft versus host disease (GvHD) after HSCT (n = 14). Group 3: healthy subjects (n = 20). A complete ophthalmological examination was undertaken in all subjects, including Schirmer's test, TBUT (break-up-time) test, Oxford scale, OSDI test, corneal tomography, and conjunctival CD8+ lymphocyte detection. Results: In Branch 1 (comparative analysis before and after HSCT in Group 1), statistically significant differences were found in the following variables: best-corrected visual acuity (BCVA) OD (P = 0.08), OSDI test (P = 0.003), TBUT OU (OD P= 0, OS P= 0.0003), Oxford test OU (OD P= 0.01, OS P= 0.0049), and CD8+ lymphocytes OU (OD P= 0.003, OS P= 0.01). In Branch 2 (comparative analysis between Group 2 and 3), the variables with statistically significant differences (P < 0.001) in OU were: BCVA, OSDI test, Schirmer's test OU, TBUT test, Oxford test, and CD8+ lymphocytes. Finally, in Branch 3 (comparative analysis between Group 1 after HSCT and Group 2), statistically significant differences (P < 0.001) were found OU: in OSDI test, Schirmer's test, and Oxford test OU; and with P < 0.005 in TBUT test OU. Conclusion: In our study, statistically significant changes were observed in the OSDI test, TBUT test, Oxford Scale, and the detection of CD8+ lymphocytes in patients who underwent HSCT. Differences were more significant in those patients who had developed GvHD after HSCT compared to those without GvHD.


How to cite this article:
Alba-Linero C, Rodriguez Calvo de Mora M, Lavado Valenzuela R, Pascual Cascón MJ, Martín Cerezo AR, Álvarez Pérez M, Recio LV, Jerez Aragonés JM, García Campos JM. Ocular surface characterization after allogeneic stem cell transplantation: A prospective study in a referral center.Indian J Ophthalmol 2020;68:1556-1562


How to cite this URL:
Alba-Linero C, Rodriguez Calvo de Mora M, Lavado Valenzuela R, Pascual Cascón MJ, Martín Cerezo AR, Álvarez Pérez M, Recio LV, Jerez Aragonés JM, García Campos JM. Ocular surface characterization after allogeneic stem cell transplantation: A prospective study in a referral center. Indian J Ophthalmol [serial online] 2020 [cited 2024 Mar 29 ];68:1556-1562
Available from: https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=2020;volume=68;issue=8;spage=1556;epage=1562;aulast=Alba-Linero;type=0