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   2018| October  | Volume 66 | Issue 10  
    Online since September 24, 2018

 
 
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REVIEW ARTICLE
Cataract surgery in diabetes mellitus: A systematic review
Aditya Kelkar, Jai Kelkar, Hetal Mehta, Winfried Amoaku
October 2018, 66(10):1401-1410
DOI:10.4103/ijo.IJO_1158_17  PMID:30249823
India is considered the diabetes capital of the world, and a significant proportion of patients undergoing cataract surgery are diabetic. Considering this, we reviewed the principles and guidelines of managing cataract in patients with diabetes. The preoperative, intraoperative, and postoperative factors are of paramount importance in the management of diabetic cataract patients. Particularly, the early recognition and treatment of diabetic retinopathy or maculopathy before cataract surgery influence the final visual outcome and play a major role in perioperative decision-making. Better understanding of various factors responsible for favorable outcome of cataract surgery in diabetic patients may guide us in better overalll management of these patients and optimizing the results.
  6,550 1,185 -
ORIGINAL ARTICLES
Allergic reactions to atropine eye drops for retardation of progressive myopia in children
Mihir Kothari, Rishika Jain, Nitu Khadse, Vivek Rathod, Shreyans Mutha
October 2018, 66(10):1446-1450
DOI:10.4103/ijo.IJO_165_18  PMID:30249831
Purpose: To report clinical manifestations of ocular allergy to atropine eye drops used for retardation of progressive myopia in children. Methods: Myopic children, who developed bothersome itching that subsided promptly after cessation of atropine eye drops, were included. History of systemic or ocular allergy, preexisting ocular conditions, and clinical features of allergy were noted. Results: Six children, age 5–15 years, were included. Four developed allergy to 1% atropine sulfate eye drops and two to 0.01% concentration of atropine sulfate. The onset of allergy was within a month to as late as 4 years after using atropine eye drops. The severity of allergy was higher with 1% concentration. The most common symptoms of atropine allergy were itching and burning. The most common signs were lid swelling and hyperemia. The allergic manifestations promptly reversed with the stoppage of eye drops. Reintroduction was possible in three patients, either by reducing the concentration of atropine or using benzalkonium free formulation. Conclusion: Allergy to atropine eye drops in children may develop within a few weeks or after many years of usage. Prompt cessation followed by a reintroduction and continuation of therapy may be possible in few patients.
  2,757 736 -
Association of the severity of meibomian gland dysfunction with dyslipidemia in Indian population
Brahm P Guliani, Abhinav Bhalla, Mayuresh P Naik
October 2018, 66(10):1411-1416
DOI:10.4103/ijo.IJO_1256_17  PMID:30249824
Purpose: To correlate the severity of meibomian gland dysfunction (MGD) with the serum lipoprotein levels. Methods: The study was conducted as a prospective observational study over a period of 18 months. Ninety patients diagnosed with MGD were enrolled after they gave their informed consent according to the inclusion–exclusion criteria. Meibomian gland status was evaluated by meibum quality, expressibility, and numerical scoring. Lipid profile was done from an overnight fasting blood sample and evaluated for total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides (TGs). Results: Patients with higher stages of MGD more often had serum TGs >150 mg/dL, total cholesterol >200 mg/dL, an LDL >130 mg/dL, and serum HDL >40 mg/dL, and there exists an association between increasing stage of MGD, and age, female sex, and increasing values of all the lipid profile components. Conclusion: A very strong association exists between increasing age and increasing severity of stage of MGD. A positive association exists between female sex and increasing severity of stage of MGD. A positive association exists between increasing severity of MGD and increasing levels of all the components of lipid profiles, namely LDL, HDL, total cholesterol, and triglycerides.
  2,840 439 -
CASE REPORTS
A rare case of persistent pupillary membrane: Case-based approach and management
Shashidhar Banigallapati, Sudhakar Potti, Himabindu Marthala
October 2018, 66(10):1480-1483
DOI:10.4103/ijo.IJO_495_18  PMID:30249846
Persistent pupillary membranes (PPMs) are a common congenital anomaly seen in 95% of neonates. Extensive PPMs, occluding the visual axis and resulting in reduced visual acuity, are relatively uncommon. We describe a case of bilateral total PPM in a 36-year-old female who presented with complaints of blurred vision in both the eyes. Dense pupillary membranes obscuring the visual axis need early surgical treatment. It is essential that the lens status remains clear along the visual axis both before and after pupilloplasty.
  2,615 282 -
GUEST EDITORIALS
Tackling the cataract backlog – An initiative by the Maharashtra State, India
Tatyarao P Lahane
October 2018, 66(10):1391-1393
DOI:10.4103/ijo.IJO_1540_18  PMID:30249820
  2,188 481 -
EDITORIAL
Is Collaborative Ocular Melanoma Study (COMS) still relevant?
Santosh G Honavar
October 2018, 66(10):1385-1387
DOI:10.4103/ijo.IJO_1588_18  PMID:30249817
  2,048 607 -
ORIGINAL ARTICLES
Trabeculectomy with subconjunctival collagen implant in Indian eyes: Long-term results
Kirti Singh, Mainak Bhattacharyya, Ankush Mutreja, Sonal Dangda
October 2018, 66(10):1429-1434
DOI:10.4103/ijo.IJO_462_18  PMID:30249827
Purpose: To report long-term safety and efficacy of trabeculectomy with collagen implant in Indian population. Methods: All cases of trabeculectomy with Ologen® Collagen Matrix implant performed over a 7-year period from May 2008 through April 2015 at a tertiary referral institute were reviewed. A total of 30 eyes of 28 patients were included in the study with two patients undergoing bilateral trabeculectomy. Outcomes measured included intraocular pressure (IOP) control, number of antiglaucoma medications used, bleb morphology, and complications/reoperations. Results: Trabeculectomy resulted in reduction in IOP from 36.46 to 11.65 mm Hg in the immediate postoperative period (day 1), a 68% decrease to 15.18 mm Hg at 84 months (58% decrease). The mean IOP reduction decreased over time from 63% in the first year to 55% after 5 years of follow-up. Fourteen eyes attained a follow-up of 5 years and eight eyes a follow-up of ≥7 years. No sight-threatening complication such as hypotony, bleb leak, and bleb-related endophthalmitis was observed in our series, and only intervention required was 5-fluorouracil needling in one case. Conclusion: Ologen-augmented trabeculectomy is effective in controlling IOP over a long-term follow up from minimal 3 to maximal 7 years. No untoward events jeopardizing bleb safety were noted at any time. This modality is a viable alternative for patients with contraindications to use of antimetabolites.
  1,731 337 -
Clinical profile of childhood blindness and inappropriate enrolment of children in schools for visually impaired in Uttar Pradesh, India
Pradeep Agarwal, Veenu Maan, Mosaib Omaer, Kunal Gupta, Lokesh Chauhan, Ashi Khurana
October 2018, 66(10):1456-1461
DOI:10.4103/ijo.IJO_1251_17  PMID:30249833
Purpose: To assess major causes of severe visual impairment (SVI)/blindness (BL) in children studying in schools for the blind in western Uttar Pradesh, India and the extent of inappropriate enrolment of children in blind schools. Methods: Students of five schools for the blind were examined in a tertiary care eye hospital. The anatomical sites and etiology for SVI/BL were recorded using the World Health Organization/Prevention of Blindness standard reporting form. Categorical variable were summarized using frequencies and percentages. Results: A total of 93 students were examined. Male/Female ratio was 3.4:1. The most common anatomical sites of SVI/BL were the whole globe (40.3%) and the cornea (26.4%). Postnatal or childhood causes were noted in 13.8% cases. Forty-one (56.9%) students had hereditary diseases which was most likely caused by chromosomal abnormalities. Three students were having an associated disability, one was deaf and mute, one was physically handicapped, and one was intellectually challenged. Fifty-four (58%) children were blind and 21 (22.6%) children had no visual impairment but were studying in schools for the blind. Conclusion: Schools for the blind should be screened routinely to reduce the incidence of misdiagnosed visual impairment. This will prevent inappropriate enrolment and will definitely help in reducing the social and economic burden of society and of the schools of blind too.
  1,632 248 -
LIVING LEGENDS IN OPHTHALMOLOGY
Living Legend in Ophthalmology - Dr Bradley R Straatsma, MD, JD

October 2018, 66(10):1388-1388
DOI:10.4103/0301-4738.242033  PMID:30249818
  1,353 482 -
CASE REPORTS
A rare case of hypereosinophilic syndrome presenting with unilateral proptosis and torticollis
Jayanta K Das, Krati Gupta, Saurabh Deshmukh, Richa Shrivastava
October 2018, 66(10):1508-1511
DOI:10.4103/ijo.IJO_316_18  PMID:30249857
Hypereosinophilic syndrome (HES) is a spectrum of myeloproliferative disorder, which is characterized by persistent and marked blood eosinophilia and damage to multiple organs due to eosinophilic infiltration. Idiopathic HES is identified after ruling out all other causes of eosinophilia. Poor prognosis is usually associated with cardiac involvement and malignant transformation of blood cells. We report a rare case of HES in an 8-year-old boy who presented with unilateral proptosis and torticollis. The patient responded well to corticosteroid therapy with reduction of proptosis and torticollis and normalization of serum eosinophil count.
  1,671 122 -
GUEST EDITORIALS
Precision medicine and clinical ophthalmology
Bradley R Straatsma
October 2018, 66(10):1389-1390
DOI:10.4103/ijo.IJO_1459_18  PMID:30249819
  1,354 382 -
COMMENTARY
Commentary: Childhood blindness in India: Regional variations
Rohit C Khanna
October 2018, 66(10):1461-1462
DOI:10.4103/ijo.IJO_1144_18  PMID:30249834
  1,410 241 -
ORIGINAL ARTICLES
Role of hyperhomocysteinemia in proliferative diabetic retinopathy: A case–control study
Prabha Gupta, Deepa John, Grace Rebekah, Sheeja S John
October 2018, 66(10):1435-1440
DOI:10.4103/ijo.IJO_350_18  PMID:30249828
Purpose: Hyperhomocysteinemia has been postulated as a potential risk factor for the development and progression of diabetic retinopathy. The aim of this study was to determine the association of hyperhomocysteinemia with proliferative diabetic retinopathy (PDR). Methods: This was a hospital-based, case–control study, conducted at a tertiary care ophthalmic center in South India. Thirty-nine patients with proliferative diabetic retinopathy were enrolled as cases, and 39 age- and gender-matched patients with no diabetic retinopathy (No DR) were enrolled as controls. Fasting serum homocysteine estimation, as well as baseline investigations, were done in all participants. Data regarding demographic profile and risk factors were documented. Data were analyzed using Chi-square test and independent t-test, as appropriate. Results: The prevalence of hyperhomocysteinemia was higher in PDR (59%) compared to “No DR” (48.7%); however, this difference was not statistically significant (P = 0.36). Similarly, the mean serum homocysteine level in cases was higher than in controls, but this was not statistically significant (17.98 + 6.26 μmol/L vs. 17.71 + 8.17 μmol/L; P = 0.87). Longer duration of diabetes, hypertension, anemia, and renal dysfunction were found to be significantly associated with PDR. Conclusion: The prevalence of hyperhomocysteinemia as well as the mean serum levels of homocysteine were found to be higher in the cases with PDR, compared to the controls with No DR, although the difference was not statistically significant. Longer duration of diabetes, hypertension, anemia, and renal dysfunction were significantly associated with PDR.
  1,316 303 -
Comparative evaluation of two toric intraocular lenses for correcting astigmatism in patients undergoing phacoemulsification
Sheetal A Seth, Rakesh K Bansal, Parul Ichhpujani, Natasha G Seth
October 2018, 66(10):1423-1428
DOI:10.4103/ijo.IJO_73_18  PMID:30249826
Purpose: To compare the efficacy of AT-TORBI plate haptic toric intraocular lens (IOL) (Carl Zeiss Meditec AG, Jena, Germany) and AcrySof loop haptic toric IOL (Alcon Laboratories, Inc., Fort Worth, TX, USA) for correcting preexisting astigmatism of ≥1 diopters (D) in patients undergoing phacoemulsification and to compare the rotational stability of these two toric IOLs. Methods: In this prospective randomized controlled trial. Forty-two eyes of 42 cataract patients with preexisting astigmatism of 1 D or more were randomized to receive plate haptic toric (AT TORBI) or loop haptic toric (AcrySof) IOLs, with 21 in each group. Postoperative evaluation was done at day 1, 1 week, 1 month, and 3 months. Uncorrected distance visual acuity (UDVA), best corrected visual acuity (VA), and IOL position were noted in both the groups. Results: At 3 months postoperatively, the mean log MAR UDVA was 0.23 ± 0.20 and 0.20 ± 0.13 in Groups I and II, respectively (P = 0.7), the mean residual cylindrical refractive error in plate haptic toric group was 0.40 ± 0.31 D and in loop haptic group was 0.45 ± 0.33 D (P = 0.64). The mean IOL rotation at 3 months follow-up in plate haptic group was found to be 3.52 ± 3.84° and in loop haptic group was 2.05 ± 2.56° (P = 0.25). Conclusion: Both types of toric IOLs were equally efficacious for attaining good uncorrected VA and correcting preexisting astigmatism between 1–5 D. Both of them were rotationally stable at 3 months follow-up.
  1,300 308 -
ONE MINUTE OPHTHALMOLOGY
Conjunctival chemosis or not?
Arpan Gandhi, Sima Das
October 2018, 66(10):1394-1394
DOI:10.4103/ijo.IJO_456_18  PMID:30249821
  1,203 375 -
CASE REPORTS
Ocular chemical burns from accidental exposure to topical dermatological medicinal agent
Jitender Jinagal, Parul C Gupta, Gaurav Gupta, Kamal K Sahu, Jagat Ram
October 2018, 66(10):1476-1477
DOI:10.4103/ijo.IJO_365_18  PMID:30249844
We report a case of accidental ocular chemical injury by self-medication with a single application of a topical ayurvedic medication containing salicylic acid, phenol, and tincture iodine, which is being used in developing countries for treatment of various dermatological conditions.
  1,295 224 -
ORIGINAL ARTICLES
Comparative studies between longitudinal and torsional modes in phacoemulsification, using active fluidics technology along with the intrepid balanced tip
Sushobhan Dasgupta, Rohan Mehra
October 2018, 66(10):1417-1422
DOI:10.4103/ijo.IJO_7_18  PMID:30249825
Purpose: To compare and report the intra- and postoperative outcomes of phacoemulsification between longitudinal (LPKE) and torsional (TPKE) mode, using active fluidics along with the intrepid balanced tip. Methods: This single center prospective randomized comparative study comprised a total 108 consecutive eyes of 108 patients having senile cataract subdivided into nuclear opalescence (NO) grades II–IV according to the lens opacities classification system III (LOCS III). Cataracts of each grade were randomly assigned to two groups LPKE (n = 54) and TPKE (n = 54) mode, who were operated on by the same surgeon using same machine (Centurion® Alcon Laboratories, Inc., USA) having features of both active fluidics and intrepid balanced tip. Pre-, intra-, and postoperative evaluations were done independently by a different author, who was masked to the surgical procedures. Patients were evaluated on the postoperative days (PODs) 1, 7, 15, and 28. Intraoperative outcome measures were cumulative dissipated energy (CDE) and ultrasound time (UST). Postoperative outcome measures were endothelial cell loss (ECL), central corneal thickness (CCT), and best-corrected visual acuity (BCVA). Results: Age, gender, and NO-grade distribution among two modes were comparable (P > 0.05). Difference of CDE and UST between modes were found to be significant (P < 0.001) in favor of TPKE with all NO-grades. TPKE mode performs better than LPKE mode with regard to ECL, CCT-change, and BCVA-change, although the differences were found to be insignificant (P > 0.05). Conclusion: When using active fluidics along with the intrepid balanced tip, TPKE mode appeared to be a more efficient mode of PKE with reduced mean UST and CDE across all NO-grades, as compared to LPKE mode. However, ECL, CCT-change, and BCVA-change were seemed to be comparable between the two modes.
  1,130 239 -
CASE REPORTS
Dramatic response to intravitreal Bevacizumab in hypertensive retinopathy
Srikant Padhy, Vinod Kumar
October 2018, 66(10):1494-1495
DOI:10.4103/ijo.IJO_214_18  PMID:30249851
Hypertensive retinopathy is seen frequently in patients with systemic hypertension and is usually asymptomatic. An acute rise in blood pressure may lead to exudative changes in the form of macular edema, hemorrhages, and serous macular detachment that can lead to visual decline. The authors report prompt resolution of exudative changes in a case of hypertensive retinopathy following intravitreal bevacizumab.
  1,155 197 -
Uveitis in sporadic Blau syndrome: Long-term follow-up of a refractory case treated successfully with adalimumab
Anmol U Naik, Radha Annamalai, Jyotirmay Biswas
October 2018, 66(10):1483-1485
DOI:10.4103/ijo.IJO_629_18  PMID:30249847
The classic entity of autosomal dominant Blau syndrome (BS) consists of arthritis, dermatitis, and uveitis, occurring as a result of mutations in the NOD2 gene pattern recognition receptor. Sporadic cases are those in which no known gene mutation is identifiable. Uveitis in BS can be refractory to conventional therapy. We report a case of sporadic Blau uveitis managed with adalimumab monotherapy after failing to respond to topical steroids, systemic steroids, methotrexate, and infliximab therapy sequentially. Uveitis resolved completely with adalimumab and the patient has had a disease-free period over a 2-year follow-up with bi-monthly injections for arthritis control.
  1,068 205 -
Necrotizing fungal infection due to Saksenaea erythrospora: A case report and review of literature
Bipasha Mukherjee, Debi Kundu
October 2018, 66(10):1513-1516
DOI:10.4103/ijo.IJO_389_18  PMID:30249859
Mucormycosis caused by Saksenaea erythrospora is an emerging infection seen with soil contamination, burns and/or nosocomial infections. PCR amplification and internal transcribed spacer sequencing is gold standard for its identification. Here, we report a case of necrotizing fungal orbital infection by S. erythrospora in an immunocompetent child.
  1,104 140 -
Retinitis as the presenting feature of subacute sclerosing panencephalitis in an Indian male: A case report
Amravi Shah, Rajesh Babu, Jyotirmoy Biswas
October 2018, 66(10):1491-1493
DOI:10.4103/ijo.IJO_251_18  PMID:30249850
Measles virus is a rare but important cause for acute retinitis as it can eventually lead to the fulminant complication of SSPE. We report a case of a young Indian male with acute viral retinitis who subsequently developed SSPE. It is of paramount importance to consider measles virus and SSPE as a cause in an immunocompetent young adult with necrotizing viral retinitis
  1,048 184 -
FEATURED ARTICLE
Mortality after deferral of treatment or no treatment for choroidal melanoma
Bradley R Straatsma, Marie Diener-West, Robert Caldwell, Robert E Engstrom, For The Collaborative Ocular Melanoma Study Group*
October 2018, 66(10):1395-1400
DOI:10.4103/ijo.IJO_1499_18  PMID:30249822
Purpose: To report mortality of patients who were eligible for enrollment in the Collaborative Ocular Melanoma Study (COMS) clinical trials of medium-sized choroidal melanoma or large-sized choroidal melanoma but chose to defer treatment or receive no melanoma treatment. Design: Prospective nonrandomized multicenter cohort study as an adjunct to COMS randomized clinical trials. Methods: Patient follow-up procedures included examinations, correspondence, telephone contacts, and National Death Index searches. Primary outcome was patient death measured by all-cause mortality. Secondary outcomes were melanoma treatment and melanoma metastasis. Results: Of 77 patients eligible for COMS clinical trials who chose to defer or receive no melanoma treatment, 61 were appropriate candidates and 45 (74%) enrolled in the natural history study (NHS). In all, 42 patients (42 eyes) had medium melanoma, and the median follow-up was 5.3 years (range, 4–10.7 years). In all, 22 patients (52%) had subsequent melanoma treatment, and 20 (48%) had no melanoma treatment. For the 42 patients, Kaplan–Meier estimate of 5-year mortality was approximately 30% [95% confidence interval (CI), 18%–47%]. For COMS medium melanoma trial, 5-year mortality was 18% (95% CI, 16%–20%), not statistically significantly different from the NHS patients. After adjusting for differences in age and longest basal diameter, the 5-year risk of death for NHS patients versus COMS trial patients was 1.54 (95% CI, 0.93–2.56). Three patients had large melanoma. Melanoma metastasis was confirmed or suspected in 8 (42%) of 19 deaths. Conclusion: Greater mortality and higher risk of death for NHS patients are probative but not conclusive evidence of a beneficial, life-extending effect of medium melanoma treatment.
  961 226 -
CASE REPORTS
A challenging case of a large intraorbital foreign body perforating the nasal septum in a child
Tanie Natung, Wakaru Shullai, Donbok Lynser, Taraprasad Tripathy
October 2018, 66(10):1511-1513
DOI:10.4103/ijo.IJO_150_18  PMID:30249858
A 5 year old boy with a history of fall from a height of about 4 feet, presented after one week with swelling, watering and discharge of the right eye. He had severe conjunctival chemosis with superior displacement of the globe. Computed Tomography (CT) showed a linear low attenuation tract in the right orbit extending from the inferolateral wall up to the left uncinate process of the ethmoid bone with increasing Hounsfield unit after 10 days. The parents did not agree for early exploration. After 10 days an exploration was done and a large linear and irregular wooden foreign body (FB) measuring 4.5 x 1.5 cm2 was removed from the right orbit and a smaller one from the nasal cavity. Four weeks post surgery, his vision was 6/9 in the right eye with the eyeball in the normal position. This case was challenging because of the late presentation, parents not agreeing for early exploration, difficulty in diagnosing by CT and a large and very deep penetrating FB.
  1,020 147 -
LETTERS TO THE EDITOR
Ophthalmology training and teaching in India: How these young ophthalmologists can become leaders of tomorrow?
Suresh K Pandey, Vidushi Sharma
October 2018, 66(10):1517-1518
DOI:10.4103/ijo.IJO_898_18  PMID:30249860
  868 177 -
OPHTHALMIC IMAGES
Atypical superior iris and retinochoroidal coloboma
Arvind M Jain, Ratnesh Ranjan, George J Manayath
October 2018, 66(10):1474-1475
DOI:10.4103/ijo.IJO_531_18  PMID:30249843
  808 163 -
ORIGINAL ARTICLES
Subsequent strabismus surgeries in patients with no prior medical records
Won Jae Kim, Myung Mi Kim
October 2018, 66(10):1451-1455
DOI:10.4103/ijo.IJO_332_18  PMID:30249832
Purpose: To investigate subsequent strabismus surgeries in patients with no prior medical record and to evaluate discrepancies between surgical findings and preoperative presumptions made based on patient self-reporting and clinical findings. Methods: The medical records of patients who underwent a subsequent strabismus surgery between January 1992 and October 2017 were retrospectively reviewed. Patients with no available medical records were included in analyses. Discrepancies between preoperative presumptions and surgical findings were investigated. Original ocular alignment and previous surgical details were presumed using alternative methods, including patient self-reporting, review old photographs of patient, and checking conjunctival scarring. Results: Eleven consecutive patients (4 females, 7 males) met the inclusion criteria. The mean age at subsequent surgery was 47.7 years (range, 23–69). Seven patients had exotropia and four patients had esotropia before the subsequent surgery. Seven patients reported originally having exotropia and four patients reported originally having esotropia. However, findings from surgical exploration did not agree with preoperative presumptions from patient self-reporting in 7 of 11 patients (7/11, 63.6%). These discrepancies included errors in the original type of strabismus (7/11, 63.6%), which eye was previously operated on (1/11, 9.1%), and number of prior surgeries (1/11, 9.1%). Conclusion: When planning a subsequent strabismus surgery in patients with no prior medical record, information obtained from the patient should be used with caution. This includes the original type of strabismus and previous surgical details.
  810 146 -
CASE REPORTS
A case of Leber's miliary aneurysms with diffuse peripheral retinal vascular sheathing
Anna Lee, Jiwon Baek, Ho Ra
October 2018, 66(10):1496-1498
DOI:10.4103/ijo.IJO_52_18  PMID:30249852
A 30-year-old female presented with macular edema and discoid exudation at the posterior pole. Diffuse vascular sheathing was observed at the peripheral retina. Fluorescein angiography revealed multiple microaneurysms at the posterior pole and leakage from the peripheral vessels. Two monthly intravitreal bevacizumab led to minimal improvement, and resolution of macular edema was achieved by an additional intravitreal triamcinolone. The findings at the posterior pole resembled those of Leber's miliary aneurysm. However, this case also demonstrated a peculiar vascular sheathing at the periphery and showed response to triamcinolone, which are evidences for an inflammatory condition.
  814 141 -
ORIGINAL ARTICLES
An experimental study to evaluate safety/toxicity of intravitreal natalizumab
Rohan Chawla, Madhu Nath, Laxmi Moksha, Tapas C Nag, Thirumurthy Velpandian
October 2018, 66(10):1441-1445
DOI:10.4103/ijo.IJO_425_18  PMID:30249830
Purpose: The purpose of this prospective experimental study was to evaluate the safety/toxicity of α4β1 integrin blockade in rabbit retina using its monoclonal antibody (Natalizumab). Methods: Twelve New Zealand albino rabbits were divided into three groups (n = 4). Unilateral intravitreal injections of three different concentrations of natalizumab were performed in every rabbit of each group (Group A: 0.625 mg, Group B: 1.25 mg, and Group C: 2.5 mg). Baseline electroretinogram (ERG) and fundus photography were performed prior to injection. At days 1, 7, and 21 postinjection, ERG and fundus photography of each eye were performed. At last follow-up, Group C animals with highest drug concentration were sacrificed and the enucleated eyes were evaluated for retinal toxicity using transmission electron microscopy (TEM). Results: No difference in ERG responses was observed in eyes injected with low and intermediate concentration of natalizumab between day 0 and day 21. Furthermore, rabbits injected intravitreally with highest dose showed reduction in amplitude of “a” wave (P = 0.0017) and a reduction in amplitude of “b” wave of ERG at day 21 (P = 0.0117). TEM revealed changes in the outer plexiform layer and inner nuclear layer, suggestive of toxicity primarily to the photoreceptor synaptic terminals and bipolar cells. Conclusion: Low-dose (0.625 mg) and intermediate-dose (1.25 mg) intravitreal injection of natalizumab appears safe for rabbit retina. However, functional and anatomical changes were observed in rabbit retina following a high-dose (2.5 mg) intravitreal injection of a monoclonal antibody blocking α4β1 integrin.
  731 218 -
SURGICAL TECHNIQUE
Surgical removal of subfoveal perfluorocarbon liquid using combined flute needle and vacuum aspiration in silicone oil-filled eyes: A novel technique to remove subfoveal PFCL
Qintuo Pan, Yuxuan Deng, Wencan Wu, Zhenquan Zhao
October 2018, 66(10):1463-1465
DOI:10.4103/ijo.IJO_1337_17  PMID:30249835
We report a procedure using a pressure-controllable flute needle to remove subfoveal retention of perfluorocarbon liquid (PFCL) under silicone oil. With a two-port pars plana approach, we used a 27-gauge dental injection needle to create a retinotomy at the farthest edge of the PFCL bubble from the fovea. A 27-gauge flute needle was then inserted into the edge of the subfoveal PFCL to aspirate it with vacuum pressure. Three patients with subfoveal retained PFCL were treated by this procedure within silicone oil tamponade 1 month after the first operation. They promptly underwent successful removal of the PFCL with postoperative retinal reattachment and good visual outcome. This procedure allows safe and early treatment for subfoveal retained PFCL. Many medical institutions around the world could implement this procedure using common dental injection needles and flute needles.
  745 200 -
CASE REPORTS
Anatomical and functional outcomes of pars plana vitrectomy for inflammatory epiretinal membrane surgery in healed toxoplasmosis infection
Vishal Raval, Srinivas Rao, Taraprasad Das
October 2018, 66(10):1485-1489
DOI:10.4103/ijo.IJO_364_18  PMID:30249848
Epiretinal membrane over macula secondary to toxoplasmosis compromises vision. We describe the outcome of pars plana vitrectomy and epiretinal membrane removal after adequate treatment of acute infection. The average age of all four male patients was 36 years (range 20–60 years). Following surgery there was an average three or more lines visual acuity improvement, restoration of foveal contour with reduction in central macular thickness. One patient developed choroidal neovascular membrane postsurgery and was effectively treated with intravitreal bevacizumab. Surgery for ERM secondary to healed toxoplasmosis infection has good anatomical outcome and reasonable visual improvement, when the surgery is done in a quiet eye.
  767 138 -
Bilateral combined central retinal artery and vein occlusion in a 3-year-old child with nephrotic syndrome
Shivani Sinha, Adoor T K Rau, Rachna V Kumar, Chaitra Jayadev, Anand Vinekar
October 2018, 66(10):1498-1501
DOI:10.4103/ijo.IJO_1332_17  PMID:30249853
Nephrotic syndrome (NS) is a common disease of childhood but ophthalmic manifestations are seldom reported. We report a rare occurrence of bilateral combined central retinal artery and vein occlusion in a 3-year-old with NS. The child presented with bilateral painless loss of vision, central pallid retinae with cherry red spots, vascular tortuosity, and retinal hemorrhages. There was delayed filling of the arteriolar circulation and a delay in arteriovenous transit time on angiography and increased central retinal thickening on optical coherence tomography. She was treated with oral steroids, subcutaneous low molecular weight heparin, and oral acetylsalicylic acid. The central retinae showed resolution of the hemorrhages, tortuosity, edema, and pallor within 3 weeks. Visual acuity recovered bilaterally to 20/360, 20/190, and 20/40 at 1, 3, and 6 weeks, respectively. We discuss the possible reasons for good recovery in our patient. Though bilateral combined central retinal artery and vein occlusion is rare in pediatric NS, the treating physician should be aware of this entity as it can be successfully managed.
  706 189 -
OPHTHALMIC IMAGES
Corneal hydrops
Parul C Gupta, Jitender Jinagal, Amit Gupta, Jagat Ram
October 2018, 66(10):1471-1471
DOI:10.4103/ijo.IJO_624_18  PMID:30249839
  703 186 -
PHOTO ESSAY
Oval sign: A retained bee stinger
Muralidhar Ramappa, Roheet Dhakal, Sunita Chaurasia
October 2018, 66(10):1466-1467
DOI:10.4103/ijo.IJO_465_18  PMID:30249836
  678 205 -
CASE REPORTS
A young woman with sudden visual field shimmering: A case report
Zahra Farzinvash
October 2018, 66(10):1504-1505
DOI:10.4103/ijo.IJO_515_18  PMID:30249855
Clomiphene citrate is a common drug used for the treatment of chronic anovulation, especially in polycystic ovary syndrome (PCOS) patients. The drug potentially has systemic and ocular side effects. Here, we present ocular side effects in a PCOS patient and emphasize the need to pay attention to visual complaints during treatment course with clomiphene citrate.
  713 139 -
Measurement of size of pigmented choroidal nevus: Superiority of multicolor imaging compared to conventional color fundus photography
Kumar Saurabh, Rupak Roy, Subham Sinharoy, Dhaivat Shah, Purna Nangia
October 2018, 66(10):1501-1503
DOI:10.4103/ijo.IJO_536_18  PMID:30249854
Choroidal nevi are benign fundus lesions that require regular follow with documentation. Conventional color fundus photography (CFP) has traditionally been used to images these lesions. Multicolor imaging (MCI) available on Spectralis spectral domain optical coherence tomography system is increasingly been tested vis-à-vis conventional CFP in various retinal diseases. We present data of the right eye of a 59-year-old gentleman with choroidal nevus who underwent conventional CFP as well as MCI. Nevus appeared orange red on MCI and its size appeared larger than the same measured on conventional CFP. We also report infrared reflectance and near infrared autofluorescence features of choroidal nevus.
  690 137 -
Infectious crystalline keratopathy post-Descemet stripping endothelial keratoplasty
Ashi Khurana, Ajit Kumar
October 2018, 66(10):1478-1480
DOI:10.4103/ijo.IJO_290_18  PMID:30249845
We report a case of a 46-year-old female who developed infectious crystalline keratopathy (ICK) after Descemet's stripping endothelial keratoplasty (DSEK). She underwent DSEK for pseudophakic corneal edema in her left eye. Ten weeks after the procedure, the patient presented with complaints of blurred vision, redness in eye, and ocular pain. Slit lamp examination revealed white nonsuppurative branching deep stromal infiltrate. Microscopic examination of the Gram-stained smear showed gram-positive cocci. Streptococcus viridans was isolated on cultures. Isolated organism was sensitive to linezolid. Based on antibiotic sensitivity report, fortified linezolid (0.2%) eye drop was started on hourly basis. After 10 weeks of topical fortified linezolid (0.2%) therapy, complete resolution of infiltrate with significant corneal scarring and vascularization was seen. Infectious crystalline keratopathy can occur after DSEK.
  651 147 -
COMMENTARY
Commentary: Ocular toxoplasma: From bench-side to clinical practice!
S Bala Murugan
October 2018, 66(10):1489-1490
DOI:10.4103/ijo.IJO_999_18  PMID:30249849
  629 168 -
CASE REPORTS
Masquerades less known: Case report of benign hair follicle tumors
Jayashree Bakthavatchalam, Jayagayathri Rajagopalan, Dayakar Yadalla
October 2018, 66(10):1506-1508
DOI:10.4103/ijo.IJO_1288_17  PMID:30249856
Benign eyelid tumors derived from hair follicles are rare and frequently misdiagnosed as basal-cell carcinoma when evaluation is based on clinical evidence alone. The discrepancy between the clinical aspect and the histological diagnosis can be as high as 30–40%, even for experienced clinicians. Unfortunately, this masquerade is not only clinical but also histological. Patients may be subjected to unnecessarily extensive surgery. We present a case report of three patients clinically diagnosed as malignancy but histopathologically proven as benign hair follicle tumors.
  683 110 -
PHOTO ESSAY
Scleritis in congenital erythropoietic porphyria – infective or inflammatory?
Pranita Sahay, Suman Dhanda, Deepali Singhal, Prafulla K Maharana, Jeewan S Titiyal, Namrata Sharma
October 2018, 66(10):1467-1468
DOI:10.4103/ijo.IJO_513_18  PMID:30249837
  656 130 -
OPHTHALMIC IMAGES
Posterior lentiglobus
Parul Chawla Gupta, Jitender Jinagal, Jagat Ram
October 2018, 66(10):1472-1473
DOI:10.4103/ijo.IJO_637_18  PMID:30249841
  640 122 -
COMMENTARY
Commentary: Role of hyperhomocysteinemia in proliferative diabetic retinopathy: A case–control study
Kim Ramasamy, Chitaranjan Mishra
October 2018, 66(10):1440-1440
DOI:10.4103/ijo.IJO_1442_18  PMID:30249829
  597 137 -
OPHTHALMIC IMAGES
Fluorescein cap: Fluorescein angiographic feature of retinal cavernous hemangioma
Madhu Kumar, Navaneetha Reddy, Vinaya Kumar Konana, Ashok Kanakamedla, Surabhi Ruia, Jayamadhury Gudimetla
October 2018, 66(10):1473-1474
DOI:10.4103/ijo.IJO_852_18  PMID:30249842
  576 146 -
Pigment sheet on lens surface
Jitender Jinagal, Parul C Gupta, Gaurav Gupta, Jagat Ram
October 2018, 66(10):1471-1472
DOI:10.4103/ijo.IJO_715_18  PMID:30249840
  526 134 -
LETTERS TO THE EDITOR
July 1 is National Doctors' Day: How to regain the lost public trust in healthcare – A different perspective
Javed Hussain Farooqui, Umang Mathur
October 2018, 66(10):1519-1520
DOI:10.4103/ijo.IJO_1159_18  PMID:30249862
  514 108 -
Is pediatric eye screening compulsory and if so when?
K S Santhan Gopal
October 2018, 66(10):1518-1519
DOI:10.4103/ijo.IJO_1243_18  PMID:30249861
  477 125 -
Comment on: Rebound inflammation after an intravitreal injection in Vogt–Koyanagi–Harada syndrome
Manish Jain
October 2018, 66(10):1522-1523
DOI:10.4103/ijo.IJO_980_18  PMID:30249865
  491 102 -
Response to comment on: Rebound inflammation after an intravitreal injection in Vogt–Koyanagi–Harada syndrome
Richa Ranjan, Manisha Agarwal
October 2018, 66(10):1523-1523
DOI:10.4103/ijo.IJO_1221_18  PMID:30249866
  442 113 -
COMMENTARY
Commentary: Discerning the porhyrias!
S Bala Murugan
October 2018, 66(10):1469-1470
DOI:10.4103/ijo.IJO_1041_18  PMID:30249838
  430 93 -
LETTERS TO THE EDITOR
Comment on: Continuous intraoperative optical coherence tomography-guided shield ulcer debridement with tuck in multilayered amniotic membrane transplantation
Pooja Jain, Neera Agrawal
October 2018, 66(10):1520-1521
DOI:10.4103/ijo.IJO_938_18  PMID:30249863
  404 92 -
Response to comment on: Continuous intraoperative optical coherence tomography-guided shield ulcer debridement with tuck in multilayered amniotic membrane transplantation
Namrata Sharma, Deepali Singhal, Prafulla K Maharana, Rahul Jain, Pranita Sahay, Jeewan S Titiyal
October 2018, 66(10):1521-1522
DOI:10.4103/ijo.IJO_1029_18  PMID:30249864
  392 95 -