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Figure 1: Polymerase chain reaction for IGH/IGK gene rearrangement in orbital marginal zone lymphoma. (a) Orbital biopsy shows an infiltrate of small, plasmacytoid, lymphocytes. (b) Immunohistochemistry for B-cell marker CD20 is positive in many cells, concerning for a B cell lymphoma. Flow cytometry was inconclusive. (c) A peak (arrow) corresponds to a polymerase chain reaction amplicon resulting from a clonal rearrangement involving the FR region of the IGH gene. (d) A peak (arrow) corresponds to a polymerase chain reaction amplicon resulting from a clonal rearrangement involving the Vk and Jk segments of the IGK gene ([a] H and E, ×150; [b] Immunoperoxidase, ×150) |
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