|Year : 1966 | Volume
| Issue : 2 | Page : 89-90
Role of non-specific protein therapy, (milk injection) in cataract surgery
KS Mehra, BB Khare, K Rajyashree
Department of Ophthalmology, College of Medical Sciences, B.H.U. Varanasi, India
|Date of Web Publication||12-Jan-2008|
K S Mehra
Department of Ophthalmology, College of Medical Sciences, B.H.U. Varanasi
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Mehra K S, Khare B B, Rajyashree K. Role of non-specific protein therapy, (milk injection) in cataract surgery. Indian J Ophthalmol 1966;14:89-90
Non-specific protein therapy, given I.M. or I.V., has been used for treatment for uveitis. Mild degree of postoperative keratitis or iritis (as noted on the first dressing done after 24 to 28 hours) was seen after cataract extraction; the degree of which varied from patient to patient. Milk injection given intramuscularly after cataract extraction, reduce the post-operative iritis and keratitis.
So we wondered how would the eye react post-operatively if milk injection were given about 16-24 hours earlier to operation.
| Materials and Methods|| |
With this view in mind, we divided our cataract patients to be operated on every operation day in two groups.
Group A: In cases under this group, milk injection of 3-5cc was given intramuscularly. The strength of the injection was considered according to the body weight of the patients. They were injected 14-18 hours before the operation. In group B cases, no milk injection was given; otherwise the preoperative preparation for cases included in both groups was same.
On the first post-operative dressing which was done after 48 hours, the degree of ciliary flush and keratitis along the section were noted and the criteria for the degree of post-operative ciliary flush and keratitis were as follows:-
1st degree -- ciliary flush absent: keratitis absent.
2nd degree -ciliary flush + , keratitis absent.
3rd degree -ciliary flush + + , small degree of keratitis present.
4th degree-ciliary flush +++, marked degree of keratitis present.
In each group of A and B. 100 patients were operated; the results of the first post-operative dressing were found to be as follows:-[Table - 1]
Thus, it was seen that post-operative ciliary flush and keratitis were much less in group A in comparison to group B.
| Discussion|| |
Various explanations have been given as to how this injection of foreign protein helps in the course of inflammation. It is said that foreign proteins stimulate adrenal cortex and thus there is an increase in production of endogenous corticosteroids. Sayer's and Sayer's have confirmed this theory on animals. Activity of adrenal cortex is judged by the amount of excretion of 17. Keto-steroids in urine and Rosen has shown that there is an increase in 17 keto-steroids in urine after protein injections. According to Wood, this non-specific protein therapy has an important role in the treatment of localised eye inflammation. As we all know. steroids do not directly act on ocular tissue but only reduce the degree of reaction of tissues to an exciting agent thereby diminishing hyper sensitivity and inflammation.
Thus, the release of corticosteroids after non-specific protein therapy, inhibit development of iritis and keratitis. Therefore, when milk injection was given intramuscularly before cataract operation, presumably the degree of post-operative iritis and keratitis was much less and the post-operative period of such patients was smooth.
For ocular diseases, either boiled fresh cow's milk or proprietary milk preparations were used for this therapy.
| Summary and Conclusion|| |
1. 100 patients of cataract extractions were given intramuscular injection (non-specific protein therapy ), 3-5 cc varying according to the weight of the patients, 18 hours before the operation while in the other group of 100 patients; no milk injection was given.
2. The degree of post-operative ciliary flush (iritis) and keratitis was noted in both the groups on the first postoperative dressing.
3. Those patients who were given milk injections before operation showed much less degree of ciliary flush and keratitis in comparison to those who were not given milk injections.
| References|| |
Rosen. D. A. (1952), Amer. J. Oohth. 35: 1783.
Sayer's and Sayer's M. A. (1949). The pituitary adrenal system. Ann. N. Y. Acad. Sci. 50: 522.
[Table - 1]