|Year : 1971 | Volume
| Issue : 3 | Page : 136-138
Methandienone (Dianabol) in corneal ulcers
KN Mathur, KK Gupta, RP Kulshrestha
G. S: V. , M. Medical College, Kanpur, India
K N Mathur
G. S: V. , M. Medical College, Kanpur
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Mathur K N, Gupta K K, Kulshrestha R P. Methandienone (Dianabol) in corneal ulcers. Indian J Ophthalmol 1971;19:136-8
|How to cite this URL:|
Mathur K N, Gupta K K, Kulshrestha R P. Methandienone (Dianabol) in corneal ulcers. Indian J Ophthalmol [serial online] 1971 [cited 2021 Mar 3];19:136-8. Available from: https://www.ijo.in/text.asp?1971/19/3/136/34977
Recent studies have shown that anabolic steroids when administered in low doses promote a rapid healing of the wounds both surgical and others: Udiipa and Singh  observed a rapid healing of fractures in comparison with untreated controls. Arborel us  used Dianabol successfully in the healing of resistant varicose ulcers of the legs. Ray  has obtained encouraging,results with this in. the treatment of corneal ulcers. With these observations in mind we tried to evaluate the role of Dianabol in cases of corneal ulcers.
Methandienone (Dianabol) is an orally active steroid which enhances protein synthesis resulting in positive Nitrogen Balance in the body. This increased protein metabolism helps in early and rapid healing of corneal ulcers.
| Material and Method|| |
For the present study a total of 129 cases were studied.
The cases were divided into two groups - first a control group who had the full treatment of corneal ulcers with mydriatics, local antibiotics, local- Heat, pad and bandage. Another group was given all this treatment but in addition to this a daily dose of Dianabol - 5mgm. in adults and 1 mgm. in children was given. Both the groups were given adequate protein diet.
For the convenience of study, the ulcers were - divided - into 5 types i.e. superficial, deep, sloughing, hypopyon and dendritic corneal ulcers.
The average relief of symptoms and signs in days, the healing time of corneal ulcers in days and the type of opacity formed were duly noted.
The weight of the patients was also noted from time to time to know any change in weight.
| Observations|| |
[Table - 2] shows the comparison of relief of signs and symptoms in average days in the control and the trial groups. The superficial ulcers in the control group healed in an average period of 10 days while in the trial group it took 7 days for healing Deep ulcers in the control group took 14 days for healing whereas in the trial group it took 10 days for healing.
Sloughing corneal ulcers healed in 20 and 16 days in the control and the trial groups respectively. Hpopyon ulcers took 20 days for healing in the control group and 17 days in the trial group. Dentritic corneal ulcers healed in 14 and 12 days respectively in the control and the trial groups but there were recurrences of the ulcers.
In the same way relief of pain, disappearance of photophobia, lacrimation, ciliary and conjunctival congestion in average days, were recorded [Table - 2].
The weight gain in the trial group was on an average 0.50 lbs/ week. There was also an increase in weight in the control group (0.263 lbs/week) due to good diet given in the Hospital.
| Discussion|| |
Corneal ulcers lead to various degrees of visual impairment depending upon the site of the scar tissue in the cornea and the density of the opacity. In India corneal opacities are responsible for a large number of blind persons and it is a major single contributory factor responsible for it.
In the healing of corneal ulcers two factors are required - first is to check the infection and the second factor is to raise the body resistance to fight the infection. Duke. Elder (1964) stated that amongst the prominent contributory factors responsible for the healing of corneal ulcers are alleviation of the general malnutrition and conjuctival bacterial flora. In the present era of antibiotics the infection can be easily controlled. As regards, general malnutrition which is prevalent in our country due to non-availability of good balanced diet and also due to dietary habits, the people should take protein rich diet and for the assimilation of proteins, Dianabol is recommended.
The above observations show that the healing time of ulcers was reduced in days in the trial groups and also there was early relief of pain and disappearance of photophobia, lacrimation ciliary and conjunctival congestion in the group which was given Dinabol therapy. The effects were marked in sloughing corneal ulcers.
The corneal opacities in the trial group were much less in density and extent as compared to the control group. It is because of the reduction of the scar tissue formation.
| Summary|| |
Majority of cases of corneal ulcers come from the poor class suffering from under nutrition or malnutrition coupled with unhygienic surroundings. In these persons Dianabol helps to restore the normal metabolism essential for proper healing of wounds. The routine corneal ulcers treatment provides control of infection and inflammation whereas Dinabol probably stimulates the healing process also.
It is concluded that Dianabol therapy can be an important adjuvant to routine corneal ulcers treatment especially when the patients are suffering from under nourishment or malnutrition.
| Acknowledgement|| |
We are thankful to Messrs 'CIBA' of India for the generous supply of Dianabol.
| References|| |
ARBORELIUS, M. (1963); Svenska Lakartidu, 60, 1.4.
DUKE-ELDER (1964); Parson's Diseases of the eye, J. & A. Churchill Ltd.
RAY, I. S. (1966); Treatment of corneal ulcers with positive Nitrogen balance, Current Medical Practice Vol. No. 10, No. 1, page 49-50.
UDAPA, K. N. and SINGH. R. H. (1964) Ind. J. Med. Rs. 52, 279.
[Table - 1], [Table - 2]