|Year : 1976 | Volume
| Issue : 4 | Page : 35-36
SP Dhir, IS Jain, SK Das
Post Graduate Institute of Medical Education and Research, Chandigarh, India
S P Dhir
Department of Ophthalmology, Post Graduate Institute of Medical Education and Research, Chandigarh
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Dhir S P, Jain I S, Das S K. Regressed retinoblastoma. Indian J Ophthalmol 1976;24:35-6
Spontaneous regression in a retinoblastoma is well documented in literature. This is, however, a rare phenomenon. Usually regression of retinoblastoma leads to a phthisical eye. Das found 3 examples of spontaneously regressed retinoblastomas in 140 eyes removed for retinoblastoma. Regressed retinoblastoma with retention of visual acuity is indeed rare. We report a case of spontaneously regressed retinoblastoma in an adult with retention of visual acuity and genetic transmission.
| Case reports|| |
A. N., 40, male presented with his son 4L years old with bilateral retinoblastomas [Figure - 1]. In one eye of the child the retinoblastoma was quiie advanced and enucleation was performed and the diagnosis confirmed histopathologically. Optic nerve was markedly infilterated with tumour cells. The other eye had a pear shaped tumour in the upper nasal quadrant 2-3 disc diametre in size. On enquiry elder daughter of the case died with bilateral white pupillary reflexes. The other two children aged 4 months and 2 years were not available for examination. His father had one eye phthisical.
The case had defective vision in right eye since childhood and there has been no improvement or further deterioration of vision in right eye ever since. On examination the visual acuity was 6/36 in RE and 6/6 in LE. There was no improvement of vision in RE with correction of refractive error. RE was divergent by 10° and took up fixation on covering the left eye. In both eyes no abnormality was detected in the anterior segment. In the right fundus ophthalmoscopically a horizontally oval yellowish white mass of the size of 3x2 disc diametre was seen in the macular area [Figure - 2]. Retinal blood vessels were seen only in the peripheral parts of the mass. Few choroidal vessels could be seen through the atrophic patch at' the periphery. The borders of the patch were well delineated. The central part of the area was bulging into the vitreous cavity with chalky white deposits more dense in the centre and scattered in the peripheral part. The eye did not reveal any signs of present or past inflammation.
| Comments|| |
The diagnosis of regressed retinoblastoma was made on the following grounds
1. Presence of calcified tumour in the fundus with characteristic clinical picture.
2. Presence of bilateral retinoblastoma in two sibs. History of phthisical eye in father.
Das on histopathological examination of 140 eyes enucleated with retinoblastoma found evidence of regression in three instances. Isolated cases of phthisical eyes showing regressed retinoblastoma have been reported by Satyaendran Mehra and Benerjee, Jain and Singh and Dayal et al. However, there is no case report in the country of a regressed retinoblastoma with retention of useful vision.
| Summary|| |
A rare case of spontaneously regressed retinoblastoma in an adult with retention of vision and genetic transmission of retinoblastoma is reported.
| References|| |
Das. S. P., 1964, J. All India Ophthal. Soc., 12,
Dayal, Y., Angra, S. K., Gahlot, D. K., Sharma, U. and Sood, N.N., 1970, Orient Arch. Ophthal.,
Jain, I. S. and Singh, K., 1968, J. All India Ophthal. Soc.,
Mehra, K. S. and Banerjee, C., 1965, Brit. J. Ophthal., 49,
Satyendran, O. M.,
Appalanarasiah, K. and Phatak, B. K., 1965 Orient. Arch. Ophthal. 3,
[Figure - 1], [Figure - 2]