|Year : 1980 | Volume
| Issue : 3 | Page : 115-116
Histamine in uveitis
Arun Kumar, V Thakur, HV Nema, KS Mehra
Department of Ophthalmology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
9, Arya Nagar, P & T Colony, Idgah Agra - Cantt
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Kumar A, Thakur V, Nema H V, Mehra K S. Histamine in uveitis. Indian J Ophthalmol 1980;28:115-6
Recurrent attacks of uveitis, inspite of all the investigations and treatment remains a problem. Undoubtedly, it is a difficult task to define cause and effect relationship in any disease process particularly more so in uveitis, wherein mole than i5% cf cases one has to remain contented with a presumptive aetiological diagnosis.
Maclean and Taylor have blamed increased uveal vascular permeability as a cause for recurrence of iridocyclitis. Gamble et a1 in their experimental work on any one have shown that severe primary inflammation of uveal tract causes a marked prolonged increase in uveal vascular permeability, which persists even in absence of clinical or histological evidence of inflammation. But what may be the reason for the persistence of increased vascular permeability in ciliary body remains a mystery. Therefore this study was carried out to find out if histamine could be responsible for the increased permeability in uveitis patients.
| Materials and methods|| |
The blood of all those patients included in the study, was collected under aseptic conditions. 'These patients had not suffered and nor were suffering from any systemic or local allergic condition. Patients showing eosinophilia were not included in the study. All necessary routine examination and investigations for uveitis were carried out in all these patients. Histamine estimation in whole blood was carried out by methodology of Clark. We divided the patients in following groups ;
Group A - Normal subjects (30)
Group B - patients suffering from granulomatous uveitis (17)
Group C - patients suffering from nongranulomatous uveitis (23)
| Observations|| |
It was observed that histamine level of blood was significantly raised in group B and Group C.
In control group whole blood histamine level varied from 2.63 mg/100 ml to 25.10 mg/ 100 ml. The corresponding figure varies from 10.00 mg/100 ml to 46.4 mg./ 100 ml and 12.25 mg./ 100 ml to 55.38 mg./ 100 ml in group B and group C respectively [Table - 1].
The statistical significance was calculated with the help of student `test which found highly significant' [Table - 1].
| Discussion|| |
It was observed that histamine concentration is raised in patients suffering from uveitis, irrespective of granulomatous or nongranulomatous, in comparison to control group.
These results suggest that histamine blood level remains raised even during acute or chronic stage. Histamine may be a very important factor in causing increased vascular permeability in ciliary body resulting in local tissue damage followed by a rebound phenomenon.
Further in our study we observe that the greater is the number of attacks, more is the histamine concentration in blood. Keeping this observation in mind we are of the opinion that systemic use of antihistaminics for a prolonged period may help the patients of uveitis.
| Summary|| |
Allergy, infection and stress have been blamed for the recurrence of iridocyclitis. Rarely, increased vascular permeability has been blamed as its cause. In this study blood histamine level was determined in 40 patients suffering from uveitis and the level was found to be significantly raised in both groups in comparison to control group.
| Acknowledgement|| |
We express our gratitude to Professor K.N. Udupa, Director, Surgical Research Lab. Banaras Hindu University, for providing the necessary facilities. Our thanks are also due to the staff of bioanalysis wing of laboratory for their co-operation during the course of the study.
| References|| |
Maclean A.L., 1936, Trans. Amer. J Ophthalmol. Soc. 34 : 324.
Taylor, F.W., 1956, Amer. J. Ophthalmol. 41:229..
Gamble C.N , Aranson, S. B. Frances, B., 1970, Arch Ophthalmol. 84 : 321.
Clarks, F.C. 1960, Method of Biochemical analysis Vol. 3, International Publisher Inc. New York 1960.
Mehra, K S., 1976, Proc. VI Afro-Asian Congress Ophthalmol. P-677.
[Table - 1]