|Year : 1982 | Volume
| Issue : 5 | Page : 427-429
Topical beta blockers and ocular tension in human eyes
YP Singh, Gopal Das, Bharti
Deptt. of Ophthalmology, S.N. Medical College & Hospital, Agra, India
Y P Singh
Deptt. of Ophthalmology, S.N. Medical College & Hospital, Agra
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Singh Y P, Das G, Bharti. Topical beta blockers and ocular tension in human eyes. Indian J Ophthalmol 1982;30:427-9
The effect of two Beta blockers Propranolol (1%, 2% & 4%) and Timolol maleate (0.25% and 0.5%) has been tested on normotensive and glaucomatous eyes. The Timolol was used only in glaucomatous eyes. Results show that both the Beta blockers have got marked hypotensive effect on normotensive and glaucomatous eye. The fall intraocular tension was higher in eyes with higher initial intraocular tension. Tachyphylaxia was seen in only 20% cases on Propranolol therapy. They both have additive effect with Pilocarpin.
The present study has been undertaken to find out the effect of B-blockers on normal intraocular pressure, in chronic simple glaucoma, narrow angle glaucoma, buphthalmos, medical measure and operation failed glaucomatous eyes.
| Materials and methods|| |
The study has been divided into 5 groups [Table - 1] :
Routine eye examination, visual acuity, ophthalmoscopy, Tonometry, water drinking or mydriatic provocative tests, visual field charting, gonioscopy, measurement of pupillary size were done,
The B-blockers used in this study
I. Propranolol 1%, 2% & 4%
2. Timolol 0. 25%, 0.5%
The heart rate, blood pressure and corneal sensation were recorded at the time of maximum effect of B-blocker eye solution and in the last, patient was asked if he noticed any itching or any discomfort after putting these drops.
| Observations and discussion|| |
Propranolol 1. Normal eyes with mean I.O.P. 18 mm. Hg. The mean maximum fall in I.O.P. in normal by 3rd hour with '1 drops was 3.4 mm. Hg ; with 2% drops it was : 4.5 mm. Hg. The control eyes showed a maximum fall of 0.7 mm. Hg. probably due to diurnal variation.
2. Glaucomatous eyes with mean I.O.P. 35 mm. Hg. The mean maximum fall in I.O.P. with 1% drops was : 5.4 mm . Hg; with 2% drops : 7.0 mm. Hg. and with 4% drops it was : 8 mm. Hg. The control eyes had a maximum drop of 1.8 mm.Hg.
In 80% cases, on follow up for 180 days, having mean initial tension 27 mm. Hg. the tension remained between 19.4 - 20.5 mm. Hg. by 2% Propranolol twice a day.
In 2 eyes of Scheie's operation failed glaucoma (Nonformation of bleb) the mean tension lowered from initial tension 28.9 to 23.0 mm. Hg. by 2% Propranolol eye drops two times a day.
In 2 eyes the addition of Propranolol 2% eye drops twice a day with Pilocarpine regime lowered the tension by 5.2 mm.. Hg.
Timolol Eye Drops The mean intraocular pressure of 29.5 mm. Hg. was lowered down to 17.7 mm. Hg. after 2 weeks of therapy with Timolol 0.25% twice a day. The greatest decrease was 15.4 mm. Hg. and the lowest was 2 5 mm. Hg. The man fall being 11.8 mm. Hg. with 0.5% Timolol twice a day for 2 weeks. The mean fall in I.O.P. was: 19.4 mm. Hg.
Additional effect of timolol was observed in 2 narrow angle glaucoma on Pilocarpine therapy and 4 open angle glaucoma on pilocarpine therapy and 2 open angle glaucoma Pilocarpine and Acetazolamide therapy, 2 buphthalmos eyes on Pilocarpine and Acetozolamide and 2 Scheie's operation failed eyes. It failed to prove additional advantage in one buphthalmos eye and one case of failed.
The beta blockers did not have any effect on pupillary size and visual acuity. There was no change in peripheral and central fields and cup-disc ratio. While Timolol did not have any effect on corneal sensation propranolol did lower the corneal sensation. Some evidence of tachyphylaxis was noticed with Propranolol but none with Timolol.
| Summary|| |
Various concentrations of Propranolol and Timolol have been evaluated to control intraocular tension.
| Acknowledgement|| |
Thanks are due to Dr. Anklesaria, of M.S.D for the supply of Timolol and Propranolol eye drops.
[Table - 1], [Table - 2]